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Title: Synthesis of an uncharged tetra-cyclopeptide acting as a transmembrane carrier : enhanced cellular and nuclear uptake.
Authors: Hilário, Flaviane Francisco
Traoré, Mohamed Dit Mady
Zwick, Vincent
Berry, Laurence
Pires, Claudia A. Simões
Cuendet, Muriel
Fantozzi, Nicolas
Freitas, Rossimiriam Pereira de
Maynadier, Marjorie
Wein, Sharon
Vial, Henri
Wong, Yung-Sing
Issue Date: 2017
Citation: HILÁRIO, F. F. et al. Synthesis of an uncharged tetra-cyclopeptide acting as a transmembrane carrier: enhanced cellular and nuclear uptake. Organic Letters, v. 19, p. 1-4, 2017. Disponível em: <>. Acesso em: 15 set. 2017.
Abstract: A small uncharged cyclopeptide scaffold inspired by a natural product and designed to undergo postfunctionalizations was used as a new transmembrane vector. A bioactive and fluorescent triazole aminocoumarin was bound to this carrier to facilitate its moving across cell and subcellular membranes, and this led to an increase in its cell toxicity.
ISSN: 1523-7052
Appears in Collections:DEQUI - Artigos publicados em periódicos

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