Synthesis of an uncharged tetra-cyclopeptide acting as a transmembrane carrier : enhanced cellular and nuclear uptake.
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2017
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A small uncharged cyclopeptide scaffold inspired
by a natural product and designed to undergo
postfunctionalizations was used as a new transmembrane
vector. A bioactive and fluorescent triazole aminocoumarin was
bound to this carrier to facilitate its moving across cell and
subcellular membranes, and this led to an increase in its cell
toxicity.
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HILÁRIO, F. F. et al. Synthesis of an uncharged tetra-cyclopeptide acting as a transmembrane carrier: enhanced cellular and nuclear uptake. Organic Letters, v. 19, p. 1-4, 2017. Disponível em: <http://pubs.acs.org/doi/ipdf/10.1021/acs.orglett.6b03776>. Acesso em: 15 set. 2017.