Please use this identifier to cite or link to this item:
http://www.repositorio.ufop.br/jspui/handle/123456789/1165| Title: | Expression and characterization of LTx2, a neurotoxin from Lasiodora sp. effecting on calcium channels. |
| Authors: | Dutra, Alexandre Augusto de Assis Sousa, Lucas Oliveira Resende, Rodrigo Ribeiro Brandão, Rogélio Lopes Kalapothakis, Evanguedes Castro, Ieso de Miranda |
| Keywords: | Calcium channel Venom Spider toxins Lasiodora cDNA Expression |
| Issue Date: | 2008 |
| Citation: | DUTRA, A. A. A. et al. Expression and characterization of LTx2, a neurotoxin from Lasiodora sp. effecting on calcium channels. Peptides, v. 29, n. 9, p. 1505-1513, set. 2008. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0196978108002131. Acesso em: 18 jul. 2012. |
| Abstract: | Here, we described the expression and characterization of the recombinant toxin LTx2, which was previously isolated from the venomous cDNA library of a Brazilian spider, Lasiodora sp. (Mygalomorphae, Theraphosidae). The recombinant toxin found in the soluble and insoluble fractions was purified by reverse phase high-performance liquid chromatography (HPLC). Ca2+ imaging analysis revealed that the recombinant LTx2 acts on calcium channels of BC3H1 cells, blocking L-type calcium channels. |
| URI: | http://www.repositorio.ufop.br/handle/123456789/1165 |
| ISSN: | 01969781 |
| metadata.dc.rights.license: | O periódico Peptides concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3266011353103. |
| Appears in Collections: | DEFAR - Artigos publicados em periódicos |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| ARTIGO_ExpressionCharacterizationNeurotoxin.pdf | 898,79 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.