Expression and characterization of LTx2, a neurotoxin from Lasiodora sp. effecting on calcium channels.

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Título:	Expression and characterization of LTx2, a neurotoxin from Lasiodora sp. effecting on calcium channels.
Autor(es):	Dutra, Alexandre Augusto de Assis Sousa, Lucas Oliveira Resende, Rodrigo Ribeiro Brandão, Rogélio Lopes Kalapothakis, Evanguedes Castro, Ieso de Miranda
Palavras-chave:	Calcium channel Venom Spider toxins Lasiodora cDNA Expression
Data do documento:	2008
Referência:	DUTRA, A. A. A. et al. Expression and characterization of LTx2, a neurotoxin from Lasiodora sp. effecting on calcium channels. Peptides, v. 29, n. 9, p. 1505-1513, set. 2008. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0196978108002131. Acesso em: 18 jul. 2012.
Resumo:	Here, we described the expression and characterization of the recombinant toxin LTx2, which was previously isolated from the venomous cDNA library of a Brazilian spider, Lasiodora sp. (Mygalomorphae, Theraphosidae). The recombinant toxin found in the soluble and insoluble fractions was purified by reverse phase high-performance liquid chromatography (HPLC). Ca2+ imaging analysis revealed that the recombinant LTx2 acts on calcium channels of BC3H1 cells, blocking L-type calcium channels.
URI:	http://www.repositorio.ufop.br/handle/123456789/1165
ISSN:	01969781
Licença:	O periódico Peptides concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3266011353103.
Aparece nas coleções:	DEFAR - Artigos publicados em periódicos

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