Immune response induced by New World Leishmania species in C57BL/6 mice.

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dc.contributor.authorMaioli, Tatiani Uceli
dc.contributor.authorTakane, Erica
dc.contributor.authorArantes, Rosa Maria Esteves
dc.contributor.authorFietto, Juliana Lopes Rangel
dc.contributor.authorAfonso, Luís Carlos Crocco
dc.date.accessioned2017-06-13T16:05:10Z
dc.date.available2017-06-13T16:05:10Z
dc.date.issued2004
dc.description.abstractIn the present study, C57BL/6 mice were inoculated with metacyclic Leishmania amazonensis or L. braziliensis promastigotes. While these animals were capable of controlling the infection by L. braziliensis, they developed chronic lesions with elevated numbers of parasites when infected by L. amazonensis. The differences in parasite control were associated with a decreased production of IFN-c and TNF by lymph node cells from L. amazonensis-infected mice. Furthermore, these animals presented decreased spleen cell proliferation and activation of germinal centers. In addition, we compared the ability of these parasites to hydrolyze extracellular ATP and AMP. While the ATPase activity of both parasite species was similar, L. amazonensis promastigotes presented higher AMP hydrolytic activity. This increased activity may lead to an increased production of adenosine, which has been shown to present anti-inflammatory activity and may thus be involved in the establishment of the immunosuppression observed in mice infected by L. amazonensis.pt_BR
dc.identifier.citationMAIOLI, T. U. et al. Immune response induced by New World Leishmania species in C57BL/6 mice. Parasitology Research, v. 94, p. 207-212, 2004. Disponível em: <http://link.springer.com/article/10.1007%2Fs00436-004-1193-6>. Acesso em: 19 fev. 2017.pt_BR
dc.identifier.doihttps://doi.org/10.1007/s00436-004-1193-6
dc.identifier.issn1432-1955
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/7965
dc.identifier.uri2http://link.springer.com/article/10.1007%2Fs00436-004-1193-6pt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.titleImmune response induced by New World Leishmania species in C57BL/6 mice.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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