Immune response induced by New World Leishmania species in C57BL/6 mice.
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Data
2004
Autores
Maioli, Tatiani Uceli
Takane, Erica
Arantes, Rosa Maria Esteves
Fietto, Juliana Lopes Rangel
Afonso, Luís Carlos Crocco
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In the present study, C57BL/6 mice were
inoculated with metacyclic Leishmania amazonensis or
L. braziliensis promastigotes. While these animals were
capable of controlling the infection by L. braziliensis,
they developed chronic lesions with elevated numbers of
parasites when infected by L. amazonensis. The differences
in parasite control were associated with a decreased
production of IFN-c and TNF by lymph node
cells from L. amazonensis-infected mice. Furthermore,
these animals presented decreased spleen cell proliferation
and activation of germinal centers. In addition, we
compared the ability of these parasites to hydrolyze
extracellular ATP and AMP. While the ATPase activity
of both parasite species was similar, L. amazonensis
promastigotes presented higher AMP hydrolytic activity.
This increased activity may lead to an increased
production of adenosine, which has been shown to
present anti-inflammatory activity and may thus be involved
in the establishment of the immunosuppression
observed in mice infected by L. amazonensis.
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MAIOLI, T. U. et al. Immune response induced by New World Leishmania species in C57BL/6 mice. Parasitology Research, v. 94, p. 207-212, 2004. Disponível em: <http://link.springer.com/article/10.1007%2Fs00436-004-1193-6>. Acesso em: 19 fev. 2017.