Antinociceptive and edematogenic activity and chemical constituents of Talinum paniculatum Willd.

Abstract

Talinum paniculatum (Portulacaceae) is popularly known in the region of Patos de Minas, Minas Gerais State, Brazil, as “Maria Gorda” or “Benção-de-Deus” and in traditional medicine it is used to treat inflammatory processes in general. After dried and fragmented, the plant was sequentially submitted to exhaustive percolation with hexane, ethyl acetate and methanol. The crude extracts were investigated for their anti-edematogenic and anti-nociceptive activities through formalin-induced paw edema model. In comparison with a non-steroidal anti-inflammatory drug (NSAID) indomethacin, the hexane and ethyl acetate extracts showed higher anti-edematogenic and anti-nociceptive activity. In addition, through phytochemical studies, from these extracts were isolated and identified potassium nitrate (1), the mixture of long chain hiodrocarbons hentriacontane (2), dotriacontane (3), tritriacontane (4) and pentatriacontane (5). heneicosanoic acid (6), the ester nonacosyl nonacosanoate (7), urea (8), 3-O-b -Dglucosyl- b -sitosterol (9); the mixture of b -sitosterol (10) and stigmasterol (11), and a pentaciclyc triterpene 3-O-acethyl-aleuritolic acid (12). X-Ray difratometry was used for the characterization of inorganic constituent. TLC, HR-CG and spectrometric methods (IR. 1H and 13C NMR) were used to identify the structures of organic compounds. To the best of our knowledge, it is the first time that compound 1 to 8 and 12 are cited as constituents of T. paniculatum.