Antinociceptive and edematogenic activity and chemical constituents of Talinum paniculatum Willd.
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Data
2010
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Resumo
Talinum paniculatum (Portulacaceae) is popularly known in the region of Patos de Minas, Minas Gerais
State, Brazil, as “Maria Gorda” or “Benção-de-Deus” and in traditional medicine it is used to treat
inflammatory processes in general. After dried and fragmented, the plant was sequentially submitted to
exhaustive percolation with hexane, ethyl acetate and methanol. The crude extracts were investigated for
their anti-edematogenic and anti-nociceptive activities through formalin-induced paw edema model. In
comparison with a non-steroidal anti-inflammatory drug (NSAID) indomethacin, the hexane and ethyl
acetate extracts showed higher anti-edematogenic and anti-nociceptive activity. In addition, through
phytochemical studies, from these extracts were isolated and identified potassium nitrate (1), the mixture
of long chain hiodrocarbons hentriacontane (2), dotriacontane (3), tritriacontane (4) and
pentatriacontane (5). heneicosanoic acid (6), the ester nonacosyl nonacosanoate (7), urea (8), 3-O-b -Dglucosyl-
b -sitosterol (9); the mixture of b -sitosterol (10) and stigmasterol (11), and a pentaciclyc
triterpene 3-O-acethyl-aleuritolic acid (12). X-Ray difratometry was used for the characterization of
inorganic constituent. TLC, HR-CG and spectrometric methods (IR. 1H and 13C NMR) were used to
identify the structures of organic compounds. To the best of our knowledge, it is the first time that
compound 1 to 8 and 12 are cited as constituents of T. paniculatum.
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Portulacaceae, Anti-edematogenic activity, Antinociceptive property
Citação
RAMOS, M. P. O. et al. Antinociceptive and edematogenic activity and chemical constituents of Talinum paniculatum Willd. Journal of Chemical And Pharmaceutical Research, v. 2, p.265-274, 2010. Disponível em: <http://www.jocpr.com/abstract/antinociceptive-and-edematogenic-activity-and-chemical-constituents-of-talinum-paniculatum-willd-474.html>. Acesso em: 10 jan. 2017.