Histopathology of Leishmania major infection : revisiting L. major histopathology in the ear dermis infection model.

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dc.contributor.authorCangussú, Silvia Dantas
dc.contributor.authorSouza, Carolina Carvalho de
dc.contributor.authorCampos, Camila França
dc.contributor.authorVieira, Leda Quercia
dc.contributor.authorAfonso, Luís Carlos Crocco
dc.contributor.authorArantes, Rosa Maria Esteves
dc.date.accessioned2015-03-03T16:39:34Z
dc.date.available2015-03-03T16:39:34Z
dc.date.issued2009
dc.description.abstractWe describe the relationship between lesion outcome and histopathological hallmarks in susceptible (BALB/c) and resistant (C57BL/6 and IL-4-deficient BALB/c) mouse strains over the course of a 12-week-infection with Leishmania major in the ear. The infiltration of mononuclear cells and polymorphonuclear cells occurred within 6 h and mononuclear cells predominated one week post-infection. Permissive intracellular growth of the pathogen was associated with non-healing lesions. In contrast, tissue damage and clearance of the parasite was observed in healing lesions and was associated with inducible nitric oxide synthase expression. The identification of the struc¬tural components of tissue reaction to the parasite in this study furthers our understanding of subjacent immune effector mechanisms.pt_BR
dc.identifier.citationCANGUSSÚ, S. D. et al. Histopathology of Leishmania major infection: revisiting L. major histopathology in the ear dermis infection model. Memórias do Instituto Oswaldo Cruz, v. 104, p. 918-922, 2009. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000600017&lng=en&nrm=iso&tlng=en>. Acesso em: 08 nov. 2014.pt_BR
dc.identifier.doihttp://dx.doi.org/10.1590/S0074-02762009000600017
dc.identifier.issn0074-0276
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/4523
dc.language.isoen_USpt_BR
dc.rights.licenseO periódico Memórias do Instituto Oswaldo Cruz permite que o Repositório Institucional da Universidade Federal de Ouro Preto (UFOP) deposite uma cópia eletrônica dos artigos publicados por esse periódico  em que ao menos um dos autores faça parte da comunidade cientifica da UFOP. Fonte: Licença concedida mediante prenchimento de formulário enviado no dia 12 dez. 2013.pt_BR
dc.subjectLeishmania majorpt_BR
dc.subjectInfectious skin diseasespt_BR
dc.subjectPathologypt_BR
dc.titleHistopathology of Leishmania major infection : revisiting L. major histopathology in the ear dermis infection model.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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