Histopathology of Leishmania major infection : revisiting L. major histopathology in the ear dermis infection model.
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Data
2009
Autores
Cangussú, Silvia Dantas
Souza, Carolina Carvalho de
Campos, Camila França
Vieira, Leda Quercia
Afonso, Luís Carlos Crocco
Arantes, Rosa Maria Esteves
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Resumo
We describe the relationship between lesion outcome and histopathological hallmarks in susceptible (BALB/c) and resistant (C57BL/6 and IL-4-deficient BALB/c) mouse strains over the course of a 12-week-infection with Leishmania major in the ear. The infiltration of mononuclear cells and polymorphonuclear cells occurred within 6 h and mononuclear cells predominated one week post-infection. Permissive intracellular growth of the pathogen was associated with non-healing lesions. In contrast, tissue damage and clearance of the parasite was observed in healing lesions and was associated with inducible nitric oxide synthase expression. The identification of the struc¬tural components of tissue reaction to the parasite in this study furthers our understanding of subjacent immune effector mechanisms.
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Palavras-chave
Leishmania major, Infectious skin diseases, Pathology
Citação
CANGUSSÚ, S. D. et al. Histopathology of Leishmania major infection: revisiting L. major histopathology in the ear dermis infection model. Memórias do Instituto Oswaldo Cruz, v. 104, p. 918-922, 2009. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000600017&lng=en&nrm=iso&tlng=en>. Acesso em: 08 nov. 2014.