Use este identificador para citar ou linkar para este item:
http://www.repositorio.ufop.br/jspui/handle/123456789/8932
Título: | In vivo antimalarial efficacy of acetogenins, alkaloids and flavonoids enriched fractions from Annona crassiflora Mart. |
Autor(es): | Pimenta, Lúcia Pinheiro Santos Garcia, Giani Martins Gonçalves, Samuel Geraldo do Vale Dionísio, Bárbara Lana Braga, Érika Martins Mosqueira, Vanessa Carla Furtado |
Palavras-chave: | Flavonoids Aporphine alkaloids |
Data do documento: | 2014 |
Referência: | PIMENTA, L. P. S. et al. In vivo antimalarial efficacy of acetogenins, alkaloids and flavonoids enriched fractions from Annona crassiflora Mart. Natural Product Research, v. online, p. 1-6, 2014. Disponível em: <http://www.tandfonline.com/doi/full/10.1080/14786419.2014.900496>. Acesso em: 20 jan. 2017. |
Resumo: | Annona crassiflora and Annonaceae plants are known to be used to treat malaria by traditional healers. In this work, the antimalarial efficacy of different fractions of A. crassiflora, particularly acetogenin, alkaloids and flavonoid-rich fractions, was determined in vivo using Plasmodium berghei-infected mice model and toxicity was accessed by brine shrimp assay. The A. crassiflora fractions were administered at doses of 12.5 mg/kg/day in a 4-day test protocol. The results showed that some fractions from woods were rich in acetogenins, alkaloids and terpenes, and other fractions from leaves were rich in alkaloids and flavonoids. The parasitaemia was significantly ( p , 0.05, p , 0.001) reduced (57–75%) with flavonoid and alkaloid-rich leaf fractions, which also increased mean survival time of mice after treatment. Our results confirm the usage of this plant in folk medicine as an antimalarial remedy. |
URI: | http://www.repositorio.ufop.br/handle/123456789/8932 |
Link para o artigo: | http://www.tandfonline.com/doi/full/10.1080/14786419.2014.900496 |
DOI: | https://doi.org/10.1080/14786419.2014.900496 |
ISSN: | 1478-6427 |
Aparece nas coleções: | DEFAR - Artigos publicados em periódicos |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
---|---|---|---|---|
ARTIGO_VivoAntimalarialEfficacy.pdf Restricted Access | 169,89 kB | Adobe PDF | Visualizar/Abrir |
Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.