Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/8932
Title: In vivo antimalarial efficacy of acetogenins, alkaloids and flavonoids enriched fractions from Annona crassiflora Mart.
Authors: Pimenta, Lúcia Pinheiro Santos
Garcia, Giani Martins
Gonçalves, Samuel Geraldo do Vale
Dionísio, Bárbara Lana
Braga, Érika Martins
Mosqueira, Vanessa Carla Furtado
Keywords: Flavonoids
Aporphine alkaloids
Issue Date: 2014
Citation: PIMENTA, L. P. S. et al. In vivo antimalarial efficacy of acetogenins, alkaloids and flavonoids enriched fractions from Annona crassiflora Mart. Natural Product Research, v. online, p. 1-6, 2014. Disponível em: <http://www.tandfonline.com/doi/full/10.1080/14786419.2014.900496>. Acesso em: 20 jan. 2017.
Abstract: Annona crassiflora and Annonaceae plants are known to be used to treat malaria by traditional healers. In this work, the antimalarial efficacy of different fractions of A. crassiflora, particularly acetogenin, alkaloids and flavonoid-rich fractions, was determined in vivo using Plasmodium berghei-infected mice model and toxicity was accessed by brine shrimp assay. The A. crassiflora fractions were administered at doses of 12.5 mg/kg/day in a 4-day test protocol. The results showed that some fractions from woods were rich in acetogenins, alkaloids and terpenes, and other fractions from leaves were rich in alkaloids and flavonoids. The parasitaemia was significantly ( p , 0.05, p , 0.001) reduced (57–75%) with flavonoid and alkaloid-rich leaf fractions, which also increased mean survival time of mice after treatment. Our results confirm the usage of this plant in folk medicine as an antimalarial remedy.
URI: http://www.repositorio.ufop.br/handle/123456789/8932
metadata.dc.identifier.uri2: http://www.tandfonline.com/doi/full/10.1080/14786419.2014.900496
ISSN: 14786427
Appears in Collections:DEFAR - Artigos publicados em periódicos

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