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Title: Flavonol triglycosides of leaves from Maytenus robusta with acetylcholinesterase inhibition.
Authors: Sousa, Grasiely Faria de
Aguiar, Mariana Guerra de
Takahashi, Jacqueline Aparecida
Alves, Tânia Maria de Almeida
Kohlhoff, Markus
Vieira Filho, Sidney Augusto
Silva, Grácia Divina de Fátima
Duarte, Lucienir Pains
Keywords: Celastraceae
Issue Date: 2017
Citation: SOUSA, G. F. et al. Flavonol triglycosides of leaves from Maytenus robusta with acetylcholinesterase inhibition. Phytochemistry Letters, v. 19, p. 34-38, 2017. Disponível em: <>. Acesso em: 29 ago. 2017.
Abstract: Although Maytenus robusta aqueous infusions of leaves are used in Brazilian traditional medicine for stomach disease treatment, only a few chemical studies of this species are found in literature. The phytochemical investigation of methanol extract from M. robusta leaves yielded the known compound kaempferol (3) and two new flavonol glycosides: kaempferol-3-O-b-D-glucopyranosyl-(1 !3)-a-Lrhamnopyranosyl-( 1 ! 2)-b-D-glucopyranoside (1) and quercetin-3-O-b-D-glucopyranosyl-(1 !3)-a-Lrhamnopyranosyl-( 1 ! 2)-b-D-glucopyranoside (2). The chemical structures of 1 and 2 were elucidated by 1D/2D NMR, ESI–MS and ESI–MS2 spectral data. It is the first time flavonoids have been reported from M. robusta. Flavonols 1 and 2 showed 66% and 80% acetylcholinesterase (AChE) inhibition, compared to 93% of the standard eserine, by the Ellman’s method. These substances are one of the few active flavonols linked to a trisaccharide chain in the literature presenting this activity, and contribute to the screening for new types of natural AChE inhibitors.
ISSN: 1874-3900
metadata.dc.rights.license: O periódico Phytochemistry Letters concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 4178720474114.
Appears in Collections:DEFAR - Artigos publicados em periódicos

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