Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/7353
Title: Complete assignments of 1h and 13c nmr data for trypanocidal eremantholide c oxide derivatives.
Authors: Guimarães, Dênia Antunes Saúde
Perry, Katia da Silva Peixoto
Raslan, Delio Soares
Chiari, Egler
Barrero, Alejandro Fernández
Oltra, Juan Enrique
Keywords: Lychnophora trichocarpha
Sesquiterpene lactone
Issue Date: 2007
Citation: GUIMARÃES, D. A. S. et al. Complete assignments of 1h and 13c nmr data for trypanocidal eremantholide c oxide derivatives. Agnetic Resonance In Chemistry, v. 45, p.1084-1087, 2007. Disponível em: <http://onlinelibrary.wiley.com/doi/10.1002/mrc.2093/epdf>. Acesso em: 10 jan. 2017.
Abstract: The chemical transformations of eremantholide C (1), a trypanocidal sesquiterpene lactone isolated from Lychnophora trichocarpha Spreng., gave five new oxide derivatives: 3 -hydroxyeremantholide C (2), 1 -formyleremantholide C (3), 1 -carboxyeremantholide C (4), 1 -carbomethoxyeremantholide C (5) and sodium 1 -carboxylate of eremantholide C (6). The 1H and 13C NMR data of all these derivatives were assigned based on 1D and 2D techniques. The derivatives were evaluated against Y and CL strains of Trypanosoma cruzi. All of them were inactive against the Y strain. Compounds 2 and 5 displayed 100% activity on the CL strain while compounds 4 and 6were partially active on the CL strain. Copyright  2007 John Wiley & Sons, Ltd.
URI: http://www.repositorio.ufop.br/handle/123456789/7353
metadata.dc.identifier.uri2: http://onlinelibrary.wiley.com/doi/10.1002/mrc.2093/epdf
metadata.dc.identifier.doi: https://doi.org/10.1002/mrc.2093
ISSN: 1097-458X
Appears in Collections:DEFAR - Artigos publicados em periódicos

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