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Title: | Complete assignments of 1h and 13c nmr data for trypanocidal eremantholide c oxide derivatives. |
Authors: | Guimarães, Dênia Antunes Saúde Perry, Katia da Silva Peixoto Raslan, Delio Soares Chiari, Egler Barrero, Alejandro Fernández Oltra, Juan Enrique |
Keywords: | Lychnophora trichocarpha Sesquiterpene lactone |
Issue Date: | 2007 |
Citation: | GUIMARÃES, D. A. S. et al. Complete assignments of 1h and 13c nmr data for trypanocidal eremantholide c oxide derivatives. Agnetic Resonance In Chemistry, v. 45, p.1084-1087, 2007. Disponível em: <http://onlinelibrary.wiley.com/doi/10.1002/mrc.2093/epdf>. Acesso em: 10 jan. 2017. |
Abstract: | The chemical transformations of eremantholide C (1), a trypanocidal sesquiterpene lactone isolated from Lychnophora trichocarpha Spreng., gave five new oxide derivatives: 3 -hydroxyeremantholide C (2), 1 -formyleremantholide C (3), 1 -carboxyeremantholide C (4), 1 -carbomethoxyeremantholide C (5) and sodium 1 -carboxylate of eremantholide C (6). The 1H and 13C NMR data of all these derivatives were assigned based on 1D and 2D techniques. The derivatives were evaluated against Y and CL strains of Trypanosoma cruzi. All of them were inactive against the Y strain. Compounds 2 and 5 displayed 100% activity on the CL strain while compounds 4 and 6were partially active on the CL strain. Copyright 2007 John Wiley & Sons, Ltd. |
URI: | http://www.repositorio.ufop.br/handle/123456789/7353 |
metadata.dc.identifier.uri2: | http://onlinelibrary.wiley.com/doi/10.1002/mrc.2093/epdf |
metadata.dc.identifier.doi: | https://doi.org/10.1002/mrc.2093 |
ISSN: | 1097-458X |
Appears in Collections: | DEFAR - Artigos publicados em periódicos |
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ARTIGO_CompleteAssignmentsH.pdf Restricted Access | 119,37 kB | Adobe PDF | View/Open |
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