Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/3864
Title: Anti-trypanosomal activity of pentacyclic triterpenes isolated from Austroplenckia populnea (Celastraceae).
Authors: Duarte, Lucienir Pains
Vieira Filho, Sidney Augusto
Silva, Grácia Divina de Fátima
Sousa, José Rego de
Pinto, Artur da Silveira
Keywords: Austroplenckia populnea
Pentacyclic triterpenes
Anti-trypanosomal activity
Growth inhibition
Issue Date: 2002
Citation: DUARTE, L. P. et al. Anti-trypanosomal activity of pentacyclic triterpenes isolated from Austroplenckia populnea (Celastraceae). Revista do Instituto de Medicina Tropical de São Paulo, São Paulo, v. 44, n.2, p. 109-112, 2002. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&nrm=iso&lng=pt&tlng=pt&pid=S0036-46652002000200010>. Acesso em: 20 ago. 2014.
Abstract: Four pentacyclic triterpenes isolated from Austroplenckia populnea and four compounds of known anti T. cruzi or anti-malarial activity were tested. Of those triterpenes tested 20_-hydroxy-tingenone showed high activity, epikatonic acid was less active, while populnilic and populninic acids were inactive against the trypanosome of the subgenus Schizotrypanum tested. Benzonidazole, nifurtimox, ketoconazole and primaquine presented a remarkable dose-dependent inhibitory effect reaching practically to a total growth inhibition of the parasite at the end of incubation time. The trypanosome tested appear to be a suitable model for preliminary screen for anti T. (S.) cruzi compounds.
URI: http://www.repositorio.ufop.br/handle/123456789/3864
metadata.dc.identifier.doi: http://dx.doi.org/10.1590/S0036-46652002000200010
ISSN: 0036-4665
metadata.dc.rights.license: A Revista do Instituto de Medicina Tropical de São Paulo permite que o Repositório Institucional da Universidade Federal de Ouro Preto (UFOP) deposite uma cópia eletrônica dos artigos publicados por esse periódico  em que ao menos um dos autores faça parte da comunidade cientifica da UFOP. Fonte: Licença concedida por email enviado no dia 06/12/2013.
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