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Título : | Myenteric plexus is differentially affected by infection with distinct Trypanosoma cruzi strains in Beagle dogs. |
Autor : | Paiva, Nívia Carolina Nogueira de Fonseca, Kátia da Silva Vieira, Paula Melo de Abreu Diniz, Lívia de Figueiredo Caldas, Ivo Santana Moura, Sandra Aparecida Lima de Veloso, Vanja Maria Guedes, Paulo Marcos da Matta Tafuri, Washington Luiz Bahia, Maria Terezinha Carneiro, Cláudia Martins |
Palabras clave : | Trypanosoma cruzi Dog Myenteric plexus |
Fecha de publicación : | 2014 |
Citación : | PAIVA, N. C. N. de et al. Myenteric plexus is differentially affected by infection with distinct Trypanosoma cruzi strains in Beagle dogs. Memórias do Instituto Oswaldo Cruz, v. 109, n. 1, p. 51-60, 2014. Disponível em: <http://www.scielo.br/pdf/mioc/v109n1/0074-0276-mioc-0074-0276130216.pdf>. Acesso em: 29 ago. 2014. |
Resumen : | Chagasic megaoesophagus and megacolon are characterised by motor abnormalities related to enteric nervous system lesions and their development seems to be related to geographic distribution of distinct Trypanosoma cruzi subpopulations. Beagle dogs were infected with Y or Berenice-78 (Be-78) T. cruzi strains and necropsied during the acute or chronic phase of experimental disease for post mortem histopathological evaluation of the oesophagus and colon. Both strains infected the oesophagus and colon and caused an inflammatory response during the acute phase. In the chronic phase, inflammatory process was observed exclusively in the Be-78 infected animals, possibly due to a parasitism persistent only in this group. Myenteric denervation occurred during the acute phase of infection for both strains, but persisted chronically only in Be-78 infected animals. Glial cell involvement occurred earlier in animals infected with the Y strain, while animals infected with the Be-78 strain showed reduced glial fibrillary acidic protein immunoreactive area of enteric glial cells in the chronic phase. These results suggest that although both strains cause lesions in the digestive tract, the Y strain is associated with early control of the lesion, while the Be-78 strain results in progressive gut lesions in this model. |
URI : | http://www.repositorio.ufop.br/handle/123456789/3619 |
ISSN : | 0074-0276 |
metadata.dc.rights.license: | O periódico Memórias do Instituto Oswaldo Cruz permite que o Repositório Institucional da Universidade Federal de Ouro Preto (UFOP) deposite uma cópia eletrônica dos artigos publicados por esse periódico em que ao menos um dos autores faça parte da comunidade cientifica da UFOP. Fonte: Licença concedida mediante prenchimento de formulário enviado no dia 12 dez. 2013. |
Aparece en las colecciones: | DEFAR - Artigos publicados em periódicos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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ARTIGO_MyentericPlexusDifferentially.pdf | 1,49 MB | Adobe PDF | Visualizar/Abrir |
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