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Título : Resveratrol induces the production of reactive oxygen species, interferes with the cell cycle, and inhibits the cell migration of bladder tumour cells with different TP53 status.
Autor : Almeida, Tamires Cunha
Melo, André Sacramento
Lima, Ana Paula Braga
Branquinho, Renata Tupinambá
Silva, Glenda Nicioli da
Palabras clave : Bladder cancer
Cell migration
Cell proliferation
Reactive oxygen species
Fecha de publicación : 2023
Citación : ALMEIDA, T. C. et al. Resveratrol induces the production of reactive oxygen species, interferes with the cell cycle, and inhibits the cell migration of bladder tumour cells with different TP53 status. Natural Product Research, v. 37, n. 22, 2023. Disponível em: <https://www.tandfonline.com/doi/full/10.1080/14786419.2022.2151007>. Acesso em: 01 ago. 2023.
Resumen : Resveratrol is a polyphenolic compound whose antitumor activity has been demonstrated in several types of cancer. However, there are few studies on its molecular mechanisms of action in bladder cancer. Therefore, we aimed to evaluate resveratrol activity in bladder tumour cells with different TP53 gene status. Cytotoxicity, cell proliferation, reactive oxygen species (ROS) production, cell migration, mutagenicity, and CDH1, CTNNBIP1, HAT1, HDAC1, MYC, and SMAD4 gene expression were evaluated. An increase in ROS after resveratrol treatment was accompanied by reduced cell viability and proliferation in all cell lines. In TP53 wild-type cells, the inhibition of cell migration was accompanied by CDH1 and SMAD4 modulation. In TP53 mutated cells, cell migration inhibition with CDH1 and CTNNB1P1 upregulation was observed. In conclusion, resveratrol has antiproliferative effect in bladder tumour cells and its mechanism of action occurred through ROS production, interference with cell cycle, and inhibition of cell migration, independent of TP53 status.
URI : http://www.repositorio.ufop.br/jspui/handle/123456789/18031
metadata.dc.identifier.uri2: https://www.tandfonline.com/doi/full/10.1080/14786419.2022.2151007
metadata.dc.identifier.doi: https://doi.org/10.1080/14786419.2022.2151007
ISSN : 1478-6427
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