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http://www.repositorio.ufop.br/jspui/handle/123456789/12212
Title: | Mangifera indica leaves extract and mangiferin modulate CB1 and PPARγ receptors and others markers associated with obesity. |
Authors: | Brito, Larissa Froede Gontijo, Douglas da Costa Toledo, Renata Celi Lopes Barcelos, Rafael Mazioli Oliveira, Alaíde Braga de Brandão, Geraldo Célio Sousa, Lirlândia Pires de Ribeiro, Sônia Machado Rocha Leite, João Paulo Viana Fietto, Luciano Gomes Queiroz, José Humberto de |
Keywords: | Adipogenesis Resistin Leptin |
Issue Date: | 2019 |
Citation: | BRITO, L. F. et al. Mangifera indica leaves extract and mangiferin modulate CB1 and PPARγ receptors and others markers associated with obesity. Journal of Functional Foods, v. 56, p. 74-83, maio 2019. Disponível em: <https://www.sciencedirect.com/science/article/pii/S1756464619301227>. Acesso em: 10 fev. 2020. |
Abstract: | This study aimed phytochemical characterization (UPLC-DAD-MS/MS) of ethanolic extract of the leaves from Mangifera indica (EMI) and Mangiferin (MAN), analysis of the cytotoxic (MTT) and anti-inflammatory potential (expression of TNF-α) of EMI and MAN in vitro. In addition, was evaluate the effect on the mRNA expression of genes (CB1, PPARγ, adiponectin, resistin and leptin) associated with adipogenesis in adipose tissue of rats fed a cafeteria diet. Thus, wistar rats were treated by gavage with EMI and MAN for several days (according to the post and co-treatments). The adipose tissue was weighed and checked the expression of different markers by RT-PCR. The presence of MAN as major compound in EMI was verified. Both EMI and MAN were not cytotoxic, with lower EMI expression of TNF-α. Furthermore, EMI and MAN had proadipogenic action on post-treatment, while in the co-treatment, EMI attenuated the effect of adipogenesis and MAN increased the adipogenic process. |
URI: | http://www.repositorio.ufop.br/handle/123456789/12212 |
metadata.dc.identifier.uri2: | https://www.sciencedirect.com/science/article/pii/S1756464619301227 |
metadata.dc.identifier.doi: | https://doi.org/10.1016/j.jff.2019.03.003 |
ISSN: | 1756-4646 |
Appears in Collections: | DEFAR - Artigos publicados em periódicos |
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ARTIGO_MangiferaIndicaLeaves.pdf Restricted Access | 770,28 kB | Adobe PDF | View/Open |
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