DECBI - Departamento de Ciências Biológicas
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Navegando DECBI - Departamento de Ciências Biológicas por Assunto "Açaí"
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Item Açaí (Euterpe oleraceae Martius) : composição química e bioatividades.(2011) Souza, Melina Oliveira de; Santos, Rinaldo Cardoso dos; Silva, Marcelo Eustáquio; Pedrosa, Maria LúciaO açaí (Euterpe oleraceae Martius) é um fruto tipicamente brasileiro e economicamente importante. Relatos populares indicam o uso medicinal do seu suco e trabalhos que descrevem sua composição química, demonstram a presença de compostos fenólicos, fibras, ácidos graxos insaturados e fitosteróis, sugerindo seu potencial como alimento funcional. Este trabalho tem como objetivo apresentar uma revisão sobre o açaí, enfatizando os seus componentes químicos e suas bioatividades in vitro e in vivo. O enfoque no açaí fundamenta-se no amplo consumo deste fruto tanto no mercado interno quanto fora do país e também nas investigações que avaliam suas propriedades funcionais. Os resultados dessas investigações mostram que este fruto exibe alta capacidade antioxidante, propriedades anti-inflamatórias e efeito hipocolesterolêmico. Diante dessas propriedades e as alegações de saúde designadas ao açaí, o estudo e o consumo deste fruto devem ser estimulados.Item The hypocholesterolemic activity of açaí (Euterpe oleracea Mart.) is mediated by the enhanced expression of the ATP-binding cassette, subfamily G transporters 5 and 8 and low-density lipoprotein receptor genes in the rat.(2012) Souza, Melina Oliveira de; Silva, Lorena Souza e; Magalhães, Cíntia Lopes de Brito; Figueiredo, Bianca Barros de; Costa, Daniela Caldeira; Silva, Marcelo Eustáquio; Pedrosa, Maria LúciaPrevious studies have demonstrated that the ingestion of açaí pulp can improve serum lipid profile in various animal models; therefore, we hypothesized that açaí pulp (Euterpe oleracea Mart.) may modulate the expression of the genes involved in cholesterol homeostasis in the liver and increase fecal excretion, thus reducing serum cholesterol. To test this hypothesis, we analyzed the expression of 7α-hydroxylase and ATP-binding cassette, subfamily G transporters (ABCG5 and ABCG8), which are genes involved with the secretion of cholesterol in the rat. We also evaluated the expression of sterol regulatory element–binding protein 2, 3-hydroxy-3-methylglutaryl CoA reductase, low-density lipoprotein receptor (LDL-R), and apolipoprotein B100, which are involved in cholesterol biosynthesis. Female Fischer rats were divided into 4 groups: the C group, which was fed a standard AIN-93 M diet; the CA group, which was fed a standard diet supplemented with 2% açaí pulp; the H group, which was fed a hypercholesterolemic diet (25% soy oil and 1% cholesterol); and the HA group, which was fed a hypercholesterolemic diet supplemented with 2% açaí pulp. At the end of the experimental period, the rats were euthanized, and their blood and livers were collected. The HA group exhibited a significant decrease in serum total cholesterol, low-density lipoprotein cholesterol, and atherogenic index and also had increased high-density lipoprotein cholesterol and cholesterol excretion in feces compared with the H group. In addition, the expression of the LDL-R, ABCG5, and ABCG8 genes was significantly increased by the presence of açaí pulp. These results suggest that açaí pulp promotes a hypocholesterolemic effect in a rat model of dietary-induced hypercholesterolemia through an increase in the expression of ATP-binding cassette, subfamily G transporters and LDL-R genes.