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Title: Cell growth on 3D microstructured surfaces.
Authors: Araujo, Wagner Wlysses Rodrigues de
Teixeira, Fernanda de Sá
Silva, Glenda Nicioli da
Salvadori, Daisy Maria Fávero
Salvadori, Maria Cecília Barbosa da Silveira
Brown, I. G.
Keywords: Biomaterials
Surface patterning
Cell aggregation
Optical microscopy
Issue Date: 2016
Citation: ARAUJO, W. W. R. de, et al. Cell growth on 3D microstructured surfaces. Materials Science & Engineering. C, Biomimetic Materials, Sensors and Systems, v. 63, p. 686-689, 2016. Disponível em: <>. Acesso em: 16 jun. 2016.
Abstract: Chinese Hamster Ovary (CHO) cell cultures were grown on surfaces lithographed with periodic 3D hexagonal microcavity array morphology. The range of microcavity size (inscribed circle diameter) was from 12 μm to 560 μm. CHO cells were grown also on flat surfaces. The characterization was performed with respect to cell growth density (number of nuclei per unit area) by fluorescence opticalmicroscopy and evaluated by correlation function analysis. We found that optimum microcavity radius was 80 μm, concerning to the maximum cell growth density, being even greater than the growth density on a flat (unstructured) substrate of the same material. This finding can be important for optimization of biotechnological processes and devices.
ISSN: 0928-4931
metadata.dc.rights.license: O periódico Materials Science and Engineering: C concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3894170945574.
Appears in Collections:DEACL - Artigos publicados em periódicos

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