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Title: Different infective forms trigger distinct immune response in experimental Chagas disease.
Authors: Vieira, Paula Melo de Abreu
Franscisco, Amanda Fortes
Machado, Evandro Marques de Menezes
Nogueira, Nívia Carolina
Fonseca, Kátia da Silva
Reis, Alexandre Barbosa
Carvalho, Andréa Teixeira de
Martins Filho, Olindo Assis
Tafuri, Washington Luiz
Carneiro, Cláudia Martins
Keywords: Trypanosoma cruzi
Chagas disease
Issue Date: 2012
Citation: VIEIRA, P. M. de A. Different infective forms trigger distinct immune response in experimental Chagas disease. Plos One, v. 7, n. 3 p. e32912, 2012. Disponível em: <>. Acesso em: 12 ago. 2014.
Abstract: Although metacyclic and blood trypomastigotes are completely functional in relation to parasite-host interaction and/or target cell invasion, they differ in the molecules present on the surface. Thus, aspects related to the variability that the forms of T. cruzi interacts with host cells may lead to fundamental implications on the immune response against this parasite and, consequently, the clinical evolution of Chagas disease. We have shown that BT infected mice presented higher levels of parasitemia during all the acute phase of infection. Moreover, the infection with either MT or BT forms resulted in increased levels of total leukocytes, monocytes and lymphocytes, specifically later for MT and earlier for BT. The infection with BT forms presented earlier production of proinflammatory cytokine TNF-a and later of IFN-c by both T cells subpopulations. This event was accompanied by an early cardiac inflammation with an exacerbation of this process at the end of the acute phase. On the other hand, infection with MT forms result in an early production of IFN-c, with subsequent control in the production of this cytokine by IL-10, which provided to these animals an immunomodulatory profile in the end of the acute phase. These results are in agreement with what was found for cardiac inflammation where animals infected with MT forms showed intense cardiac inflammation later at infection, with a decrease in the same at the end of this phase. In summary, our findings emphasize the importance of taking into account the inoculums source of T. cruzi, since vectorial or transfusional routes of T. cruzi infection may trigger distinct parasite-host interactions during the acute phase that may influence relevant biological aspects of chronic Chagas disease.
ISSN: 1932-6203
metadata.dc.rights.license: Os trabalhos publicados na Plos one estão sob Licença Creative Commons que permite copiar, distribuir e transmitir o trabalho, desde que sejam citados o autor e licenciante. Não permite o uso para fins comerciais nem a adaptação. Fonte: Plos one <>. Acesso em: 03 jan. 2017.
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