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http://www.repositorio.ufop.br/jspui/handle/123456789/17574
Título: | Chrysin inhibits the cell viability, induces apoptosis and modulates expression of genes related to epigenetic events in bladder cancer cells. |
Autor(es): | Lima, Ana Paula Braga Melo, André Sacramento Ferreira, Gabriel Monteze Silva, Glenda Nicioli da |
Palavras-chave: | Flavonoid Bladder tumor Cell death Epigenetic events |
Data do documento: | 2022 |
Referência: | LIMA, A. P. B. et al. Chrysin inhibits the cell viability, induces apoptosis and modulates expression of genes related to epigenetic events in bladder cancer cells. Natural Product Research, v. 1, p. 1877-1881, set. 2022. Disponível em: <https://www.tandfonline.com/doi/epdf/10.1080/14786419.2022.2121825?needAccess=true&role=button>. Acesso em: 01 ago. 2023. |
Resumo: | This study was conducted with the aim of exploring the molecular and cellular mechanisms of action of the chrysin (natural flavonoid compound) on bladder tumour cell lines with different status of TP53 (RT4, 5637 and T24). The cells were treated with different concentrations of chrysin (20, 40, 60, 80 and 100 mM) to analyze the cell viability, nuclear division index, mutagenicity, apoptosis rates and expression of genes related to epigenetic events (DNMT1, HAT1 and HDAC1). Results showed that the treatment with chrysin reduced the cell viability and caused apoptosis, regardless TP53. Moreover, in the TP53-mutated cell lines, chrysin modulated the expression of the DNMT1, HAT1 and HDAC1 epigenetic genes, which might be a plus to the death observed in the cells with p53 mutation. |
URI: | http://www.repositorio.ufop.br/jspui/handle/123456789/17574 |
Link para o artigo: | https://www.tandfonline.com/doi/epdf/10.1080/14786419.2022.2121825?needAccess=true&role=button |
DOI: | https://doi.org/10.1080/14786419.2022.2121825 |
ISSN: | 1478-6427 |
Aparece nas coleções: | DEACL - Artigos publicados em periódicos |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
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ARTIGO_ChrysinInhibtsCell.pdf Restricted Access | 938,06 kB | Adobe PDF | Visualizar/Abrir |
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