Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/jspui/handle/123456789/17574
Title: Chrysin inhibits the cell viability, induces apoptosis and modulates expression of genes related to epigenetic events in bladder cancer cells.
Authors: Lima, Ana Paula Braga
Melo, André Sacramento
Ferreira, Gabriel Monteze
Silva, Glenda Nicioli da
Keywords: Flavonoid
Bladder tumor
Cell death
Epigenetic events
Issue Date: 2022
Citation: LIMA, A. P. B. et al. Chrysin inhibits the cell viability, induces apoptosis and modulates expression of genes related to epigenetic events in bladder cancer cells. Natural Product Research, v. 1, p. 1877-1881, set. 2022. Disponível em: <https://www.tandfonline.com/doi/epdf/10.1080/14786419.2022.2121825?needAccess=true&role=button>. Acesso em: 01 ago. 2023.
Abstract: This study was conducted with the aim of exploring the molecular and cellular mechanisms of action of the chrysin (natural flavonoid compound) on bladder tumour cell lines with different status of TP53 (RT4, 5637 and T24). The cells were treated with different concentrations of chrysin (20, 40, 60, 80 and 100 mM) to analyze the cell viability, nuclear division index, mutagenicity, apoptosis rates and expression of genes related to epigenetic events (DNMT1, HAT1 and HDAC1). Results showed that the treatment with chrysin reduced the cell viability and caused apoptosis, regardless TP53. Moreover, in the TP53-mutated cell lines, chrysin modulated the expression of the DNMT1, HAT1 and HDAC1 epigenetic genes, which might be a plus to the death observed in the cells with p53 mutation.
URI: http://www.repositorio.ufop.br/jspui/handle/123456789/17574
metadata.dc.identifier.uri2: https://www.tandfonline.com/doi/epdf/10.1080/14786419.2022.2121825?needAccess=true&role=button
metadata.dc.identifier.doi: https://doi.org/10.1080/14786419.2022.2121825
ISSN: 1478-6427
Appears in Collections:DEACL - Artigos publicados em periódicos

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