Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/jspui/handle/123456789/12173
Title: The effect of benznidazole dose among the efficacy outcome in the murine animal model. A quantitative integration of the literature.
Authors: Molina, Israel
Melo, Luísa Helena Perin de
Aviles, Augusto Sao
Vieira, Paula Melo de Abreu
Fonseca, Kátia da Silva
Cunha, Lucas Maciel
Carneiro, Cláudia Martins
Keywords: Chagas disease
Trypanosoma cruzi
Clinical trial
Issue Date: 2020
Citation: MOLINA, I. et al. The effect of benznidazole dose among the efficacy outcome in the murine animal model. A quantitative integration of the literature. Acta Tropica, v. 201, p. 105218, jan. 2020. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0001706X19303833?via%3Dihub>. Acesso em: 10 fev. 2020.
Abstract: Despite more than 100 years since it was firstly described Chagas disease, only two drugs are available to treat Chagas disease: Nifurtimox launched by Bayer in 1965 and benznidazole launched by Roche in 1971. Drug discovery initiatives have been looking for new compounds as an alternative to these old drugs. Although new platforms have been used with the latest technologies, a critical step on that process still relies on the in vivo model. Unfortunately, to date, available animal models have limited predictive value and there is no standardization. With the aim to better understand the role of benznidazole, the current standard of care of Chagas disease, we performed this review. We intend to analyze the influence of the experimental design of the most used animal model, the murine model, in the assessment of the efficacy endpoint.
URI: http://www.repositorio.ufop.br/handle/123456789/12173
metadata.dc.identifier.doi: https://doi.org/10.1016/j.actatropica.2019.105218
ISSN: 0001-706X
metadata.dc.rights.license: This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/). Fonte: o próprio artigo.
Appears in Collections:DEACL - Artigos publicados em periódicos

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