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Title: Synthesis, in vitro and in vivo anti-Trypanosoma cruzi and toxicological activities of nitroaromatic Schiff bases.
Authors: Almeida, Tamires Cunha
Ribeiro, Luis Henrique Gonzaga
Santos, Luiza Braga Ferreira dos
Silva, Cleiton Moreira da
Branquinho, Renata Tupinambá
Lana, Marta de
Gadelha, Fernanda Ramos
Fátima, Angelo de
Keywords: Aldimines
Protozoan parasite
Trypanocidal activity
Chagas disease
Issue Date: 2018
Citation: ALMEIDA, T. C. et al. Synthesis, in vitro and in vivo anti-Trypanosoma cruzi and toxicological activities of nitroaromatic Schiff bases. Biomedicine & Pharmacotherapy, v. 108, p. 1703-1711, dez. 2018. Disponível em: <>. Acesso em: 21 fev. 2019.
Abstract: Chagas disease is a major health problem not only in Latin America but also in Europe and North America due to the spread of this disease into nonendemic areas. In terms of global burden, this major tropical infection is considered to be one of the most neglected diseases, and there are currently only two available chemotherapies: benznidazole and nifurtimox. Unfortunately, although these chemotherapies are beneficial in the acute phase of the disease, benznidazole and nifurtimox lead to significant side effects, including hepatitis and neurotoxicity. Therefore, the search for and development of more effective, safe and inexpensive anti-Trypanosoma cruzi drugs are required. In this work, a series of 10 nitroaromatic Schiff bases bearing different (nitro) aromatic rings-was synthesized. Subsequently, the in vitro and in vivo anti-T. cruzi activities of the Schiff bases were investigated, as well as the in vivo toxicity and the biological effects. The basic structure of the most promising in vivo Schiff base, 10 would be useful in the synthesis of new compounds for Chagas disease treatment.
ISSN: 07533322
metadata.dc.rights.license: This is an open access article under the CC BY-NC-ND license ( Fonte: o próprio artigo.
Appears in Collections:DEACL - Artigos publicados em periódicos

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