Use este identificador para citar ou linkar para este item: http://www.repositorio.ufop.br/handle/123456789/1043
Título: Parasite density and impaired biochemical/hematological status are associated with severe clinical aspects of canine visceral leishmaniasis.
Autor(es): Reis, Alexandre Barbosa
Martins Filho, Olindo Assis
Carvalho, Andréa Teixeira de
Carvalho, Maria das Graças
Mayrink, Wilson
Silva, João Carlos França da
Giunchetti, Rodolfo Cordeiro
Genaro, Odair
Oliveira, Rodrigo Corrêa de
Palavras-chave: Canine visceral leishmaniasis
Leishmania infantum
Parasite density
Biochemical/hematological status
Data do documento: 2006
Referência: REIS, A. B. et al. Parasite density and impaired biochemical/hematological status are associated with severe clinical aspects of canine visceral leishmaniasis. Research in veterinary Science, v. 81, n.1, p.68-75, ago. 2006. Disponível em: http://ac.els-cdn.com/S0034528805001748/1-s2.0-S0034528805001748-main.pdf?_tid=4f1cbe4e253ec8c80d331aaeea953a43&acdnat=1334946917_b1f2a830d785250464a5eb42d5649d8e. Acesso em: 10 jul. 2012.
Resumo: We have performed a detailed investigation in 40 dogs naturally infected withLeishmania infantum ( syn. chagasi), subdivided into three groups: asymptomatic (AD = 12), oligosymptomatic (OD = 12) and symptomatic (SD = 16), based on their clinical features. Twenty non-infected dogs (CD) were included as control group. Serological analysis, performed by IFAT and ELISA, demonstrated higher antibodies titers in SD in comparison to the AD. A positive correlation was found between parasite density in the spleen and skin smears as well as the bone marrow parasitism with clinical status of the infection. We observed that the progression of the disease from asymptomatic to symptomatic clinical form was accompanied by intense parasitism in the bone marrow. It is likely that this led to the impaired biochemical/hematological status observed. Finally, we believe that the follow-up of these parameters could be a relevant approach to be used as markers during therapeutic and vaccine evaluations.
URI: http://www.repositorio.ufop.br/handle/123456789/1043
ISSN: 00345288
Licença: O Periódico Research in Veterinary Science concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3291410100627
Aparece nas coleções:DEACL - Artigos publicados em periódicos 2

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