Barcellos, Luiz Alexandre Medrado deGonçalves, William AntonioOliveira, Marcos Paulo Esteves deGuimarães, Juliana BohnenQueiroz Júnior, Celso MartinsResende, Carolina Braga deRusso, Remo de CastroCoimbra, Cândido CelsoSilva, Albená Nunes daTeixeira, Mauro MartinsGonçalves, Barbara Maximino RezendeSilva, Vanessa Pinho da2021-08-202021-08-202021BARCELLOS, L. A. M. et al. Effect of physical training on exercise-induced inflammation and performance in mice. Frontiers in Cell and Developmental Biology, v. 9, fev. 2021. Disponível em: <https://www.frontiersin.org/articles/10.3389/fcell.2021.625680/full>. Acesso em: 10 jun. 2021.2296-634Xhttp://www.repositorio.ufop.br/jspui/handle/123456789/13556Acute exercise increases the amount of circulating inflammatory cells and cytokines to maintain physiological homeostasis. However, it remains unclear how physical training regulates exercise-induced inflammation and performance. Here, we demonstrate that acute high intensity exercise promotes an inflammatory profile characterized by increased blood IL-6 levels, neutrophil migratory capacity, and leukocyte recruitment to skeletal muscle vessels. Moreover, we found that physical training amplified leukocyte– endothelial cell interaction induced by acute exercise in skeletal muscle vessels and diminished exercise-induced inflammation in skeletal muscle tissue. Furthermore, we verified that disruption of the gp-91 subunit of NADPH-oxidase inhibited exerciseinduced leukocyte recruitment on skeletal muscle after training with enhanced exercise time until fatigue. In conclusion, the training was related to physical improvement and immune adaptations. Moreover, reactive oxygen species (ROS) could be related to mechanisms to limit aerobic performance and its absence decreases the inflammatory response elicited by exercise after training.en-USabertoMuscular inflammationNeutrophilOxidative stressArtigo publicado em periodicoThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Fonte: o PDF do artigo.https://doi.org/10.3389/fcell.2021.625680