Custódio, Carlos Henrique XavierMiranda, José Rodolfo RubiniYamaguchi, JulianaSilveira, Kátia Daniela daTeixeira, Mauro MartinsChianca Júnior, Deoclécio AlvesSilva, Ana Cristina Simões eSantos, Robson Augusto Souza dosCamargo, Antônio Carlos Martins deIanzer, Danielle Alves2017-11-272017-11-272017XAVIER, C. H. et al. Bj-PRO-5a and Bj-PRO 10c found at c-type natriuretic peptide precursor of bothrops jararaca change renal function of hypertensive rats. International Journal of Peptide Research And Therapeutics, v. 25, p. 1-5, 2017. Disponível em: <https://link.springer.com/article/10.1007/s10989-017-9575-7>. Acesso em: 15 set. 2017.1573-3904 http://www.repositorio.ufop.br/handle/123456789/9187Proline-rich oligopeptides from Bothrops jararaca (Bj-PROs) produce potent and long-lasting antihypertensive effect through mechanisms that go beyond ACE inhibition. In this study we evaluated the renal function parameters of spontaneously hypertensive rats (SHR) injected with Bj-PRO-5a and -10c (0.47, 71 or 710 nmol/ kg) found in the CNP-precursor of the snake. At 71 and 710 nmol/kg, Bj-PROs increased urinary flow rate (18.1– 43.5%). At 71 nmol/kg, Bj-PRO 5a and 10c elevated sodium excretion (68.1 and 40.9%, respectively) and Bj- PRO-5a also increased urinary sodium/creatinine ratio (56.5%). At 0.47 nmol/kg, Bj-PROs did not change renal function. All doses of Bj-PROs reduced blood pressure (Δ = −13 to −24mmHg). We conclude that Bj-PROs reduce blood pressure and improve renal functien-USrestritoBlood pressureHeart rateHypertensionProlinerich oligopeptidesRenal functionArtigo publicado em periodicohttps://link.springer.com/article/10.1007/s10989-017-9575-7https://doi.org/10.1007/s10989-017-9575-7