Nizer, Waleska Stephanie da CruzFerraz, Ariane CoelhoLima, William Gustavo deMoraes, Thaís de Fátima SilvaFerreira, Fernanda LopesFerreira, Jaqueline Maria SiqueiraMagalhães, Cíntia Lopes de BritoDuarte, Lucienir PainsVieira Filho, Sidney AugustoMagalhães, José Carlos de2019-04-042019-04-042018NIZER, W. S. da C. et al. Evaluation of the activity of Tontelea micrantha extracts against Bacteria, Candida and Mayaro virus. Journal of Pharmaceutical Negative Results, v. 9, n. 1, p. 21-26, 2018. Disponível em: <http://www.pnrjournal.com/article.asp?issn=0976-9234;year=2018;volume=9;issue=1;spage=21;epage=26;aulast=Cruz;type=0>. Acesso em: 22 fev. 2019.22297723http://www.repositorio.ufop.br/handle/123456789/10948Objectives: This work aimed to evaluate the antibacterial, antifungal, and anti-Mayaro virus(MAYV) activity of leaf and branch extracts from Tontelea micrantha. Materials and Methods: T. micrantha extracts were prepared through the partition of the leaf and branch samples in different solvents. Then, the antibacterial and antifungal activity was assessed against bacterial pathogens and Candida sp. by the determination of the minimum inhibitory concentration (MIC) by the broth microdilution method. The activity against anti-MAYV was evaluated through the quantification of the extract concentration that promoted the protection of 50% of the cells after the viral infection. Results: The extracts of T. micrantha were inactive (MIC >500 µg/mL) against Gram-positive, Gram-negative and Candida species at the highest concentration tested (500 µg/mL). Anti-MAYV activity was also not detected, with SI <10, ranging from 1.2 to 3.6. Conclusion: Although it is used in traditional medicine, Leaf and branch extracts from T. micrantha did not present antimicrobial activity, which could be caused by the antagonistic effect of the compounds present in the extract.en-USabertoAntimicrobial activityLeaf extractsBranch extractsArtigo publicado em periodicoThis is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. Fonte: o próprio artigo.