Barbosa, Helloana AzevedoSilva, Guilherme Álvaro Ferreira daSilva, Carolina FariaSouza, Thiago Belarmino deDias, Danielle FerreiraPaula, Ana Cláudia Chagas deIonta, MarisaCarvalho, Diogo Teixeira2020-05-222020-05-222019BARBOSA, H. A. et al. Phenylpropanoid-based sulfonamide promotes cyclin D1 and cyclin E downregulation and induces cell cycle arrest at G1/S transition in estrogen positive MCF-7 cell line. Toxicology in Vitro, v. 59, p. 150-160, set. 2019. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0887233318305290?via%3Dihub>. Acesso em: 10 fev. 2020.0887-2333http://www.repositorio.ufop.br/handle/123456789/12249Cancer is one of the most critical problems of public health in the world and one of the main challenges for medicine. Different biological effects have been reported for sulfonamide-based compounds including antibacterial, antifungal, and antitumor activities. Herein, a series of phenylpropanoid-based sulfonamides (4a, 4a′, 4b, 4b′, 5a, 5a′, 5b and 5b′) were synthesized and their cytotoxic activity was evaluated against four cell lines derived from human tumours (A549 – lung, MCF-7 – breast, Hep G2 - hepatocellular carcinoma, and HT-144-melanoma). Cell viability was significantly reduced in the MCF-7 cell line when compounds 4b, 4b′ and 5a were used; IC50 values were lower than those found for their precursors (eugenol and dihydroeugenol) and sulfanilamide. We observed that 4b induced cell cycle arrest at G1/S transition. This is probably due to its ability to reduce cyclin D1 and cyclin E expression. Moreover, 4b also induced apoptosis in MCF-7 cells as demonstrated by an increase in the cell population positive for annexin V in treated cultures in comparison to the control group. Taken together, the data showed that 4b is a promising antitumor agent and it should be considered for further in vivo studies.en-USrestritoSulfonamidesMolecular hybridizationAntiproliferative activityBreast cancerArtigo publicado em periodicohttps://www.sciencedirect.com/science/article/pii/S0887233318305290https://doi.org/10.1016/j.tiv.2019.04.023