Antigenicity of a whole parasite vaccine as promising candidate against canine leishmaniasis.

Giunchetti, Rodolfo CordeiroReis, Alexandre BarbosaLemos, Denise da SilveiraMartins Filho, Olindo AssisOliveira, Rodrigo Corrêa deBethony, Jeffrey MichaelVale, André MacedoQuetz, Josiane da SilvaBueno, Lilian LacerdaSilva, João Carlos França daNascimento, Evaldo doMayrink, WilsonFujiwara, Ricardo Toshio2012-07-052012-07-052008GIUNCHETTI, R. C. et al. Antigenicity of a whole parasite vaccine as promising candidate against canine leishmaniasis. Veterinary Science, v. 85, n. 1, p. 106-112, ago. 2008. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0034528807002263>. Acesso em: 05 jul. 2012.03784312http://www.repositorio.ufop.br/handle/123456789/976Human visceral leishmaniasis, one of the most important zoonoses, is caused by the protozoaLeishmania chagasi(syn. L. infantum ) and is present as a fatal disease common in South America and Europe where dogs and wild canids are the main reservoirs. A vaccine against visceral leishmaniasis would be an important tool in the control of this disease in dogs. Although the current strategies for vac-cination against leishmaniasis are based on the use of recombinant antigens, killed vaccines are still attractive in terms of stability of their biochemical composition and antigenicity, cost, and safety. Here we evaluate the immunogenicity of a whole parasite vaccine as a prom-ising candidate against canine leishmaniasis, demonstrated by cellular reactivity, changes in the cellular profile of the peripheral blood and by the differential production of immunoglobulins. Our results showed that immunization elicited mainly a strong cellular reactivity and increase in T-lymphocytes, particularly the subpopulation CD8 + that would be related to the control of tissue parasitism. In addi-tion, a higher production of anti- Leishmania total IgG, characterized by mixed isotypes profile (IgG1 and IgG2), was demonstrated.en-USVaccineCanine visceral leishmaniasisWhole parasite vaccineDogAntigenicity of a whole parasite vaccine as promising candidate against canine leishmaniasis.Artigo publicado em periodicoO periódico Research in Veterinary Science concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3347180559130.