Borgati, Tatiane FreitasPereira, Guilherme RochaBrandão, Geraldo CélioSantos, Juliana de OliveiraFernandes, Dayane Aparecida MoraisPaula, Renata Cristina deNascimento, Maria Fernanda Alves doSoares, Luciana FerreiraLopes, Júlio César DiasSouza Filho, José Dias deOliveira, Alaíde Braga de2017-08-302017-08-302017BORGATI, T. F. et al. Synthesis by click reactions and antiplasmodial activity of Lupeol 1,2,3-Triazole derivatives. Journal of the Brazilian Chemical Society, v. 00, p. 1-7, 2017. Disponível em: <http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0103-50532017001001850&lng=pt&nrm=iso>. Acesso em: 29 ago. 2017.1678-4790http://www.repositorio.ufop.br/handle/123456789/8597Lupeol, a triterpene frequently found in Asteraceae plant species, showed moderate to low activity in different strains of Plasmodium falciparum, the most virulent malaria etiological agents. In this work, lupeol was isolated from Parahancornia fasciculata, a plant that is used to treat malaria in the Amazonia region. In the search of more activity lupeol derivatives, five new 1,2,3-triazole hybrid molecules were synthetized by copper-catalyzed azide-alkyne cycloaddition. The antiplasmodial activity of the semi-synthetic compounds were evaluated by the lactate dehydrogenase assay; the lupeol propargyl ether was the only one to disclosing increased activity (half maximal inhibitory concentration-IC50-62.0 ± 1.92 μmol L-1) in relation to lupeol (IC50 117.00 μmol L-1). Therefore, this work revealed a new class of interesting lupeol derivatives that can be obtained by linking electron donors to the hydroxy group at C-3.en-USabertoTerpenoidsClick chemistryArtigo publicado em periodicoOs trabalhos publicados no periódico Journal of the Brazilian Chemical Society, exceto onde identificado, está sob licença Creative Commons que permite copiar, distribuir e transmitir o trabalho em desde que sejam citados o autor e o licenciante. Fonte: Journal of the Brazilian Chemical Society <http://www.scielo.br/scielo.php?script=sci_serial&pid=0103-5053&lng=en&nrm=iso>. Acesso em: 23 jan. 2020.http://dx.doi.org/10.21577/0103-5053.20170013