High prevalence of dengue antibodies and the arginine variant of the FcγRIIa polymorphism in asymptomatic individuals in a population of Minas Gerais State, Southeast Brazil.

Pereira, Anna Carolina Toledo da CunhaSiqueira, Tatiane Ribeiro dePrado, Andressa Anunciação de OliveiraSilva, Camila Almeida Veiga daMoraes, Thaís de Fátima SilvaAleixo, Alan AlexMagalhães, José Carlos deSouza, Gabriel Augusto Pires deDrumond, Betânia PaivaFerreira, Gustavo PortelaSilva, Breno de MelloMagalhães, Cíntia Lopes de BritoSantos, Luciana LaraFerreira, Jaqueline Maria SiqueiraMalaquias, Luiz Cosme CottaCoelho, Luiz Felipe Leomil2018-05-032018-05-032017PEREIRA, A. C. T. da C. et al. High prevalence of dengue antibodies and the arginine variant of the FcγRIIa polymorphism in asymptomatic individuals in a population of Minas Gerais State, Southeast Brazil. Immunogenetics, vol. 1, p. 1-8, 2017. Disponível em: <https://link.springer.com/article/10.1007%2Fs00251-017-1046-y>. Acesso em: 05 abr. 2018.14321211 http://www.repositorio.ufop.br/handle/123456789/9892Dengue is the most prevalent arthropod-borne viral illness in humans worldwide. Single-nucleotide polymorphisms (SNPs) in genes involved in the immune response, such as dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN), IgG Fc receptor II-A (FcγRIIa), vitamin D receptor (VDR), and tumor necrosis factor alpha (TNF-α), were previously reported to be associated with susceptibility to dengue disease in different human populations. Therefore, due to the relevant association of host immune and genetic status with disease susceptibility/severity of dengue, this work aims to verify the frequency of anti-dengue virus antibodies and some dengue-associated risk SNPs in a population in Minas Gerais State, Southeast Brazil. A total of 1560 individuals were genotyped for polymorphisms in DC-SIGN (rs4804803), FcγRIIa (rs1801274), VDR (rs7975232), and TNF-α (rs1800629). The presence of anti-dengue antibodies (IgM and/or IgG) in these samples was also assayed. Anti-dengue antibodies were detected at an overall frequency of 16.86%, indicating a virus infection in asymptomatic individuals. The genotypic frequencies of all SNPs studied did not differ between the asymptomatic and control groups. Regarding the allelic frequencies of the four SNPs analyzed, a higher frequency was detected of the G allele of FcγRIIa/rs1801274 in the asymptomatic individuals when compared to that in the control group (p =0.03). Therefore, the results showed a high prevalence of asymptomatic individuals in Minas Gerais State, with a potential association between the presence of the G allele of FcγRIIa/rs1801274 and protection against symptomatic disease.en-USrestritoDengueAsymptomatic patientsHigh prevalence of dengue antibodies and the arginine variant of the FcγRIIa polymorphism in asymptomatic individuals in a population of Minas Gerais State, Southeast Brazil.Artigo publicado em periodicohttps://link.springer.com/article/10.1007%2Fs00251-017-1046-y