Oliveira, Marcos Felipe Andrade deSilva, André Talvani Pedrosa daVieira, Etel Rocha2019-04-022019-04-022019OLIVEIRA, M. F. A. de; SILVA, A. T. P. da; VIEIRA, E. R. IL-33 in obesity : where do we go from here? Inflammation Research, v. 68, n. 3, p. 185–194, mar. 2019. Disponível em: <https://link.springer.com/article/10.1007%2Fs00011-019-01214-2>. Acesso em: 22 fev. 2019.1420908Xhttp://www.repositorio.ufop.br/handle/123456789/10904IL-33 is a cytokine that belongs to the IL-1 family and is classically associated with type 2-like immune responses. In the adipose tissue, IL-33 is related to the beiging of adipocytes and to the maintenance of adipose tissue-resident immune cells, such as innate lymphoid cells 2, alternatively activated macrophages and regulatory T cells, which contribute to the maintenance of adipose tissue homeostasis. In the obese adipose tissue, the number of these cells is diminished, unlike the expression of IL-33, which is up-regulated. However, despite its increased expression, IL-33 is not able to maintain the homeostasis of the obese adipose tissue. IL-33 treatment, on the other hand, highly improves obesity-related inflammatory and metabolic alterations. The evidence that exogenous IL-33, but not adipose tissue-driven IL-33, regulates the inflammatory process in obesity leaves a gap in the understanding of IL-33 biology. Thus, in this review we discuss the potential mechanisms associated with the impaired action of IL-33 in obesity.en-USrestritoType 2 innate lymphocyteST2; metabolismBeige adipocyteInflammationArtigo publicado em periodicohttps://link.springer.com/article/10.1007%2Fs00011-019-01214-2