Oliveira, Denise Aline de JesusAmaral, Juliano GeraldoGarcia, Laryana BorgesSantos, Milena Soares dosSilva, Lorena A. O.Almeida, Maiara Prates deGomes, Angélica FerrazBarros, Danielle Rocha PinhoLopes, Norberto PeporinePereira, Gislaine RibeiroSantos, Orlando David Henrique dosRuela, André Luís Morais2021-12-072021-12-072021OLIVEIRA, D. A. J. et al. Associating chitosan and microemulsion as a topical vehicle for the administration of herbal medicines. Carbohydrate Polymers, v. 255, p. 117482, 2021. Disponível em: <https://www.sciencedirect.com/science/article/abs/pii/S0144861720316556>. Acesso em: 10 jun. 2021.0144-8617http://www.repositorio.ufop.br/jspui/handle/123456789/14107A viscous solution of low molecular weight chitosan (CH) at 5% w/v (10.2 kDa, 75 % deacetylated, 1451 cP at 25 ◦C) was associated with a microemulsion (ME) that undergoes a phase transition after water absorption in situ (≈28 % w/w), forming a more viscous liquid crystal, which was potentially evaluated as a topical vehicle. The ME was selected from a phase diagram, selecting a composition based on Tween® 80 (52 %), myristate isopropyl (28 %), and the aqueous phase (water and polyethylene glycol 400, 60:40 w/w) (20 %), which was after replaced by CH and herbal medicines (HM). HM are alternatives to treat candidiasis, and Stryphnodendron adstringens shell extract, characterized by molecular networking, and Melaleuca alternifolia Chell essential oil (46 % of terpinen-4- ol), showed in vitro activity against Candida albicans. Associating CH in ME improved the mechanical properties of the topical formulation, as adhesiveness, which is an advantageous feature for the topical treatment of vul vovaginal candidiasis.en-USrestritoLiquid crystalAdhesivenessRheologyMolecular networkingArtigo publicado em periodicohttps://www.sciencedirect.com/science/article/abs/pii/S0144861720316556https://doi.org/10.1016/j.carbpol.2020.117482