Pala, DanielaCândido, Ana Paula CarlosCruz, Larissa Leandro daBarbosa, Priscila OliveiraSilva, Carla TeixeiraVolp, Ana Carolina PinheiroCoelho, George Luiz Lins MachadoFreitas, Renata Nascimento de2017-11-172017-11-172016PALA, D. et al. Vaspin association with insulin resistance is related to physical activity and body fat in Brazilian adolescents - a cross-sectional study. Nutrición Hospitalaria, v. 33, p. 588-594, 2016. Disponível em: <http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112016000300013&lng=es&nrm=iso&tlng=en>. Acesso em: 29 ago. 2017.0212-1611http://www.repositorio.ufop.br/handle/123456789/9156Background: Vaspin is a newly-identifi ed adipocytokine associated with insulin resistance (IR). Objective: The aim of this study was to investigate the correlation between plasma vaspin concentrations and IR and determine whether this association is affected by body composition, physical activity and pubertal stage in adolescents. Methods: Were studied 484 Brazilian adolescents aged 10–14 years whose anthropometric, clinical, biochemical, and lifestyle measurements were analized. We evaluated the correlation between vaspin and risk factors for IR in adolescents with normal and high body fat percentage (%BF) and did a logistic regression to calculate the odds ratio for IR according to vaspin quartiles sex specifi c for the sample. Results: Vaspin was positively correlated with IR in adolescents with high %BF (r = 0.23, p = 0.003). The logistic regression analysis adjusted for sex, age, BMI, and pubertal stage showed that adolescents in the 2nd (OR = 0.43, 95% CI = 0.23-0.80, p = 0.008) and 3rd (OR = 0.46, 95% CI = 0.25-0.85, p = 0.014) quartile of vaspin concentration had a lower risk for IR. When the model was adjusted for %BF and physical activity, the association remained statically signifi cant only for adolescents in the 2nd quartile. Conclusion: Vaspin was correlated positively with risk factors associated with insulin metabolism in adolescents with high %BF. Vaspin was associated with a reduced risk of IR independently of BMI and pubertal stage and the association was infl uenced by body fat and physical activity in these adolescents.en-USabertoRisk factorsArtigo publicado em periodicoOs trabalhos publicados no periódico Nutricion Hospitalaria, exceto onde identificado, está sob uma licença Creative Commons que permite copiar, distribuir e transmitir o trabalho em qualquer suporte ou formato desde que sejam citados o autor e o licenciante. Não permite o uso para fins comerciais nem a adaptação. Fonte: Nutricion Hospitalaria <http://scielo.isciii.es/scielo.php?script=sci_serial&pid=0212-1611 >. Acesso em: 25 jun. 2019.http://dx.doi.org/10.20960/nh.265