Chaves, Bárbara AparecidaOrfanó, Alessandra da SilvaNogueira, Paula MonalisaRodrigues, Nilton BarnabéCampolina, Thaís BonifácioPimenta, Rafael NacifPires, Ana Clara Araújo MachadoVieira Junior, Ademir BentesPaz, Andréia da CostaVaz, Evelyn Beatriz da CostaGuerra, Maria das Graças Vale BarbosaSilva, Breno de MelloMelo, Fabrício Freire deNorris, Douglas EricLacerda, Marcus Vinícius Guimarães dePimenta, Paulo Filemon PaolucciSecundino, Nagila Francinete Costa2019-04-022019-04-022018CHAVES, B. A. et al. Coinfection with Zika Virus (ZIKV) and dengue virus results in preferential ZIKV transmission by vector bite to vertebrate host. The Journal of Infectious Diseases, v. 218, n. 4, p. 563–571, ago. 2018. Disponível em: <https://academic.oup.com/jid/article/218/4/563/4962451>. Acesso em: 22 fev. 2019.15376613http://www.repositorio.ufop.br/handle/123456789/10908Background. Several tropical cities are permissive to Aedes aegypti and dengue virus (DENV) endemicity and have allowed for invasion and circulation of Zika virus (ZIKV) in the same areas. People living in arbovirus-endemic regions have been simultaneously infected with ≥2 arboviruses. Methods. A. aegypti mosquitoes from Manaus, the capital city of Amazonas State in Brazil, were coinfected with circulating strains of DENV and ZIKV. The coinfected vectors were allowed to bite BALB/c mice. Results. A. aegypti from Manaus is highly permissive to monoinfection and coinfection with DENV and ZIKV and is capable of cotransmitting both pathogens by bite. Coinfection strongly influences vector competence, favoring transmission of ZIKV to the vertebrate host. Conclusions. This finding suggests that A. aegypti is an efficient vector of ZIKV and that ZIKV would be preferentially transmitted by coinfected A. aegypti. Coinfection in the vector population should be considered a new critical epidemiological factor and may represent a major public health challenge.en-USabertoAedes aegyptiArtigo publicado em periodicoThis is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/ by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. Fonte: o próprio artigo