Silva, Elisângela F.Orsi, MarianaAndrade, Ângela LeãoDomingues, Rosana ZacariasSilva, Breno de MelloAraújo, Helena Rocha Corrêa dePimenta, Paulo Filemon PaolucciDiamond, Michael S.Rocha, Eliseu S. O.Kroon, Erna GeessienMalaquias, Luiz Cosme CottaCoelho, Luiz Felipe Leomil2017-03-162017-03-162012SILVA, E. F. et al. A tetravalent dengue nanoparticle stimulates antibody production in mice. Journal of Nanobiotechnology, v. 10, p. 13, 2012. Disponível em: <https://jnanobiotechnology.biomedcentral.com/articles/10.1186/1477-3155-10-13> Acesso em: 19 fev. 2017.1477-3155http://www.repositorio.ufop.br/handle/123456789/7383Dengue is a major public health problem worldwide, especially in the tropical and subtropical regions of the world. Infection with a single Dengue virus (DENV) serotype causes a mild, self-limiting febrile illness called dengue fever. However, a subset of patients experiencing secondary infection with a different serotype progresses to the severe form of the disease, dengue hemorrhagic fever/dengue shock syndrome. Currently, there are no licensed vaccines or antiviral drugs to prevent or treat dengue infections. Biodegradable nanoparticles coated with proteins represent a promising method for in vivo delivery of vaccines.pt-BRabertoInactivated Dengue vírusNanoparticlesHumoral responseArtigo publicado em periodicoThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: o próprio artigo.https://doi.org/10.1186/1477-3155-10-13