Almeida, Roberto Farina deSouza, Diogo OnofreNonose, YasmineGanzella, MarceloLoureiro, Samanta OliveiraRocha, AndréiaMachado, Daniele GuilhermanoBellaver, BrunaFontella, Fernanda UrruthLeffa, Douglas TeixeiraPettenuzzo, Letícia FerreiraVenturin, Gianina TeribeleGreggio, SamuelCosta, Jaderson Costa daZimmer, Eduardo RigonElisabetsky, Elaine2023-05-112023-05-112021ALMEIDA, R. F. de et al. Antidepressant-like effects of chronic guanosine in the olfactory bulbectomy mouse model. Frontiers in Psychiatry, v. 12, artigo 701408, 2021. Disponível em: <https://www.frontiersin.org/articles/10.3389/fpsyt.2021.701408/full>. Acesso em: 11 out. 2022.1664-0640http://www.repositorio.ufop.br/jspui/handle/123456789/16554Major depressive disorder (MDD) leads to pervasive changes in the health of afflicted patients. Despite advances in the understanding of MDD and its treatment, profound innovation is needed to develop fast-onset antidepressants with higher effectiveness. When acutely administered, the endogenous nucleoside guanosine (GUO) shows fast- onset antidepressant-like effects in several mouse models, including the olfactory bulbectomy (OBX) rodent model. OBX is advocated to possess translational value and be suitable to assess the time course of depressive-like behavior in rodents. This study aimed at investigating the long-term behavioral and neurochemical effects of GUO in a mouse model of depression induced by bilateral bulbectomy (OBX). Mice were submitted to OBX and, after 14 days of recovery, received daily (ip) administration of 7.5 mg/kg GUO or 40 mg/kg imipramine (IMI) for 45 days. GUO and IMI reversed the OBX-induced hyperlocomotion and recognition memory impairment, hippocampal BDNF increase, and redox imbalance (ROS, NO, and GSH levels). GUO also mitigated the OBX-induced hippocampal neuroinflammation (IL-1, IL-6, TNF-α, INF-γ, and IL-10). Brain microPET imaging ([18F]FDG) shows that GUO also prevented the OBX-induced increase in hippocampal FDG metabolism. These results provide additional evidence for GUO antidepressant-like effects, associated with beneficial neurochemical outcomes relevant to counteract depression.en-USabertoMajor depressive disorderPsychopharmacologyPurines - source: MeSHPurinergic signalingArtigo publicado em periodicoThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Fonte: o PDF do artigo.https://doi.org/10.3389/fpsyt.2021.701408