Jara, Carlos PobleteBerti, Beatriz de AndradeMendes, Natália FerreiraEngel, Daiane FátimaZanesco, Ariane MariaSouza, Gabriela Freitas Pereira deBezerra, Renan de MedeirosBagatin, Julia de ToledoEngler, Silvya Stuchi MariaMorari, JoseaneVelander, William H.Velloso, Licio AugustoAraújo, Eliana Pereira2023-01-162023-01-162021JARA, C. P. et al. Glutamic acid promotes hair growth in mice. Scientifc Reports, v. 11, 2021. Disponível em: <https://www.nature.com/articles/s41598-021-94816-y>. Acesso em: 11 out. 2022.2045-2322http://www.repositorio.ufop.br/jspui/handle/123456789/15941Glutamic acid is the main excitatory neurotransmitter acting both in the brain and in peripheral tissues. Abnormal distribution of glutamic acid receptors occurs in skin hyperproliferative conditions such as psoriasis and skin regeneration; however, the biological function of glutamic acid in the skin remains unclear. Using ex vivo, in vivo and in silico approaches, we showed that exogenous glutamic acid promotes hair growth and keratinocyte proliferation. Topical application of glutamic acid decreased the expression of genes related to apoptosis in the skin, whereas glutamic acid increased cell viability and proliferation in human keratinocyte cultures. In addition, we identifed the keratinocyte glutamic acid excitotoxic concentration, providing evidence for the existence of a novel skin signalling pathway mediated by a neurotransmitter that controls keratinocyte and hair follicle proliferation. Thus, glutamic acid emerges as a component of the peripheral nervous system that acts to control cell growth in the skin. These results raise the perspective of the pharmacological and nutritional use of glutamic acid to treat skin diseases.en-USabertoArtigo publicado em periodicoThis article is licensed under a Creative Commons Attribution 4.0 International License, w. Source: The article PDF.hich permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Fonte: o PDF do artigo.https://doi.org/10.1038/s41598-021-94816-y