Pinto, Isabelle CristinaSeibert, Janaína BrandãoPinto, Luciano SilvaSantos, Vagner RodriguesSousa, Rafaela F. deSousa, Lucas Resende DutraAmparo, Tatiane RoqueteSantos, Viviane Martins Rebello dosNascimento, Andréa Mendes doSouza, Gustavo Henrique Bianco deVasconcellos, Walison ArthusoVieira, Paula Melo de AbreuAndrade, Ângela Leão2021-12-092021-12-092020PINTO, I. C. et al. Preparation of glass-ionomer cement containing ethanolic Brazilian pepper extract (Schinus terebinthifolius Raddi) fruits: chemical and biological assays. Scientific Reports, v. 10, artigo 22312, 2020. Disponível em: <https://www.nature.com/articles/s41598-020-79257-3>. Acesso em: 10 jun. 2021.2045-2322http://www.repositorio.ufop.br/jspui/handle/123456789/14158Plants may contain benefcial or potentially dangerous substances to humans. This study aimed to prepare and evaluate a new drug delivery system based on a glass-ionomer-Brazilian pepper extract composite, to check for its activity against pathogenic microorganisms of the oral cavity, along with its in vitro biocompatibility. The ethanolic Brazilian pepper extract (BPE), the glass-ionomer cement (GIC) and the composite GIC-BPE were characterized by scanning electron microscopy, attenuated total refectance Fourier transform infrared spectroscopy (ATR-FTIR), and thermal analysis. The BPE compounds were identifed by UPLC–QTOF–MS/MS. The release profle of favonoids and the mechanical properties of the GIC-BPE composite were assessed. The favonoids were released through a linear mechanism governing the difusion for the frst 48 h, as evidenced by the Mt √ /M∞ relatively to t, at a difusion coefcient of 1.406 × 10–6 cm2 s−1. The ATR-FTIR analysis indicated that a chemical bond between the GIC and BPE components may have occurred, but the compressive strength of GIC-BPE does not difer signifcantly from that of this glass-ionomer. The GIC-BPE sample revealed an ample bacterial activity at non-cytotoxic concentrations for the human fbroblast MRC-5 cells. These results suggest that the prepared composite may represent an alternative agent for endodontic treatment.en-USabertoArtigo publicado em periodicoThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Fonte: o PDF do artigo.https://doi.org/10.1038/s41598-020-79257-3