Giunchetti, Rodolfo CordeiroOliveira, Rodrigo Corrêa deMartins Filho, Olindo AssisCarvalho, Andréa Teixeira deRoatt, Bruno MendesSoares, Rodrigo Dian de Oliveira AguiarSouza, Juliana Vitoriano deMoreira, Nádia das DoresMalaquias, Luiz Cosme CottaCastro, Luciana Lisboa Mota eLana, Marta deReis, Alexandre Barbosa2012-07-102012-07-102007GIUNCHETTI, R. C. et al. Immunogenicity of a killed Leishmania vaccine with saponin adjuvant in dogs. Vaccine, v. 25, n. 44, p. 7674-7686, nov. 2007. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0264410X07009255>. Acesso em: 10 jul. 2012.0264410Xhttp://www.repositorio.ufop.br/handle/123456789/1039Cellular and humoral immune responses of dogs to a candidate vaccine, composed of Leishmania braziliensis promastigote protein plus saponin as adjuvant, have been investigated as a pre-requisite to understanding the mechanisms of immunogenicity against canine visceral leishmaniasis (CVL). The candidate vaccine elicited strong antigenicity related to the increases of anti- Leishmania IgG isotypes, together with higher levels of lymphocytes, particularly of circulating CD8 + T-lymphocytes and Leishmania chagasi antigen-specific CD8 + T-lymphocytes. As indicated by the intense cell proliferation and increased nitric oxide production during in vitro stimulation by L. chagasisoluble antigens, the candidate vaccine elicited an immune activation status potentially compatible with effective control of the etiological agent of CVL.en-USCanine visceral leishmaniasisSaponin adjuvantCelland humoral immune responseArtigo publicado em periodicoO periódico Vaccine concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3291410072386.