Rezende, Simone AparecidaGollob, Kenneth JohnOliveira, Rodrigo Corrêa deGoes, Alfredo Miranda de2014-11-202014-11-201998REZENDE, S. A. et al. Down modulation of MHC surface molecules on B cells by suppressive immune complexes obtained from chronic intestinal schistosomiasis patients. Immunology Letters, v. 62, p. 67-73, 1998. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0165247898000261#>. Acesso em: 28 ago. 2014.0165-2478http://www.repositorio.ufop.br/handle/123456789/4024Granulomatous inflammation around parasite eggs is the prominent lesion in human schistosomiasis. Studies have suggested the involvement of a series of suppressive mechanisms in the control of this reaction, such as macrophages, cytokines, idiotipic interactions and immune complexes (IC). The studies examine the role of IC obtained from chronic intestinal schistosomiasis patients (ISP) in the reactivity of peripheral blood mononuclear cells (PBMC). The results have shown that these immune complexes are able to suppress cell reactivity by inducing an increase in the production of soluble mediators such as prostaglandins and IL-10. To gain a better understanding of how this suppression occurs the present study examines the phenotypic pattern of PBMC after immune complex treatment in cell proliferation assays. These data show that cultures including immune complex present a higher percentage of B lymphocytes in which a lower expression of a MHC-class II gene product, HLA-DR was detected. This altered expression of the HLA-DR molecule on B lymphocytes after IC treatment suggests a novel mechanism for the suppression observed, that is, IC might decrease the antigen-presenting function of B lymphocytes.en-USSchistosomaImmune complexesAntigen presentingArtigo publicado em periodicoO periódico Immunology Letters concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3460890344545.https://doi.org/10.1016/S0165-2478(98)00026-1