Teixeira, Aniely dos ReisQuaresma, Amanda de VasconcelosBranquinho, Renata TupinambáSantos, Stephanie Lourrani Evangelista NevesMagalhães, Juliana TeixeiraSilva, Fábio Henrique Rodrigues daMarques, Maria Betânia de FreitasMoura, Sandra Aparecida Lima deBarboza, Ana Paula MoreiraAraújo, Marcelo Gonzaga de FreitasSilva, Gisele Rodrigues da2023-10-182023-10-182023TEIXEIRA, A. dos R. et al. Miconazole-loaded nanoparticles coated with hyaluronic acid to treat vulvovaginal candidiasis. European Journal of Pharmaceutical Sciences, v. 188, artigo 106508, set. 2023. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0928098723001380?via%3Dihub>. Acesso em: 01 ago. 2023.0928-0987http://www.repositorio.ufop.br/jspui/handle/123456789/17595Miconazole-loaded nanoparticles coated with hyaluronic acid (miconazole-loaded nanoparticles/HA) were developed to overcome the limitations of the conventional therapy of the vulvovaginal candidiasis (VVC). They were synthesized by emulsification and solvent evaporation techniques, characterized by diameter, poly- dispersity index, zeta potential, encapsulation efficiency, atomic force microscopy (AFM), evaluated in terms of efficacy against C. albicans in vitro, and tested in a murine VVC model. Nanoparticles showed 211nm of diameter with a 0.32 polydispersity index, -53mV of zeta potential, and 90% miconazole encapsulation efficiency. AFM evidenced nanoparticles with a spherical shape. They inhibited the proliferation of C. albicans in vitro and in vivo after a single administration. Nanoparticles released the miconazole directly in the site of action at low thera- peutic doses, which was enough to eliminate the fungal burden in the murine VVC model. These systems were rationally designed since the existence of the HA induces their adhesion on the vaginal mucus and their inter- nalization via CD44 receptors, inhibiting the C. albicans. Therefore, miconazole-loaded nanoparticles/HA represent an innovative non-conventional pharmaceutical dosage form to treat the VVC and recurrent VVC.en-USabertoRecurrent vulvovaginal candidiasisArtigo publicado em periodicoThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/). Fonte: PDF do artigo.https://doi.org/10.1016/j.ejps.2023.106508