Soares, Everton RochaLima, Wanderson Geraldo deMachado, Raquel do PilarCarneiro, Cláudia MartinsSilva, Marcelo EustáquioRodrigues, Míriam CarmoCastro, Uberdan Guilherme Mendes deSantos, Robson Augusto Souza dosSantos, Maria José Campagnole dosAlzamora, Andréia Carvalho2015-11-262015-11-262011SOARES, E. R. et al. Cardiac and renal effects induced by different exercise workloads in renovascular hypertensive rats. Brazilian Journal of Medical and Biological Research, v. 44, p. 573-582, 2011. Disponível em: <http://www.scielo.br/pdf/bjmbr/v44n6/816.pdf>. Acesso em 21 out. 2015.0100-879Xhttp://www.repositorio.ufop.br/handle/123456789/5844We examined the effect of exercise training (Ex) without (Ex 0%) or with a 3% workload (Ex 3%) on different cardiac and renal parameters in renovascular hypertensive (2K1C) male Fisher rats weighing 150-200 g. Ex was performed for 5 weeks, 1 h/day, 5 days/week. Ex 0% or Ex 3% induced similar attenuation of baseline mean arterial pressure (MAP, 119 ± 5 mmHg in 2K1C Ex 0%, N = 6, and 118 ± 5 mmHg in 2K1C Ex 3%, N = 11, vs 99 ± 4 mmHg in sham sedentary (Sham Sed) controls, N = 10) and heart rate (HR, bpm) (383 ± 13 in 2K1C Ex 0%, N = 6, and 390 ± 14 in 2K1C Ex 3%, N = 11 vs 371 ± 11 in Sham Sed, N = 10). Ex 0%, but not Ex 3%, improved baroreflex bradycardia (0.26 ± 0.06 ms/mmHg, N = 6, vs 0.09 ± 0.03 ms/mmHg in 2K1C Sed, N = 11). Morphometric evaluation suggested concentric left ventricle hypertrophy in sedentary 2K1C rats. Ex 0% prevented concentric cardiac hypertrophy, increased cardiomyocyte diameter and decreased cardiac vasculature thickness in 2K1C rats. In contrast, in 2K1C, Ex 3% reduced the concentric remodeling and prevented the increase in cardiac vasculature wall thickness, decreased the cardiomyocyte diameter and increased collagen deposition. Renal morphometric analysis showed that Ex 3% induced an increase in vasculature wall thickness and collagen deposition in the left kidney of 2K1C rats. These data suggest that Ex 0% has more beneficial effects than Ex 3% in renovascular hypertensive rats.en-USCardiac and renal remodelingBaroreflex bradycardiaRenovascular hypertensionArtigo publicado em periodicoTodo o conteúdo do periódico Brazilian Journal of Medical and Biological Research, exceto onde identificado, está sob uma licença Creative Commons que permite copiar, distribuir e transmitir o trabalho em qualquer suporte ou formato desde que sejam citados o autor e o licenciante. Fonte: Brazilian Journal of Medical and Biological Research <http://www.scielo.br/scielo.php?script=sci_serial&pid=0100-879X&lng=en&nrm=iso>. Acesso em: 19 ago. 2019.http://dx.doi.org/10.1590/S0100-879X2011007500049