Brandão, Geane PeroniMelo, Maria NormaCaetano, Bráulia CostaCarneiro, Cláudia MartinsSilva, Letícia de AzevedoVitor, Ricardo Wagner de Almeida2012-09-112012-09-112011BRANDÃO, G. P. et al. Susceptibility to re-infection in C57BL/6 mice with recombinant strains of Toxoplasma gondii. Experimental Parasitology, v. 128, n. 4, p. 433–437, ago. 2011. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0014489411001640>. Acesso em: 11 set. 2012.00144894http://www.repositorio.ufop.br/handle/123456789/1382This work reports results of re-infection of BALB/c and C57BL/6 mice with different recombinant strains of Toxoplasma gondii. Mice were prime-infected with the non-virulent D8 strain and challenged with virulent strains. PCR–RFLP of cS10-A6 genetic marker of T. gondii demonstrated that BALB/c mice were reinfected with the EGS strain, while C57BL/6 mice were re-infected with the EGS and CH3 strains. Levels of IFN-c and IL-10 after D8 prime-infection were lower in C57BL/6 than in BALB/c mice. Brain inflammation after D8 prime-infection was more intense in C57BL/6 than in BALB/c mice. It was shown that reinfection depends on mice lineage and genotype of the strain used in the challenge.en-USExperimental toxoplasmosisRe-infectionRecombinant strainsArtigo publicado em periodicoO periódico Experimental Parasitology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3280861265494.