Swimming training induces liver adaptations to oxidative stress and insulin sensitivity in rats submitted to high-fat diet.

Zacarias, Aline CruzBarbosa, Maria AndréaCota, Renata Guerra de SáCastro, Uberdan Guilherme Mendes deBezerra, Frank SilvaLima, Wanderson Geraldo deCardoso, Leonardo MáximoSantos, Robson Augusto Souza dosSantos, Maria José Campagnole dosAlzamora, Andréia Carvalho2017-11-272017-11-272017ZACARIAS, A. C. et al. Swimming training induces liver adaptations to oxidative stress and insulin sensitivity in rats submitted to high-fat diet. Redox Report, p. 1-9, 2017. Disponível em: <http://www.tandfonline.com/doi/full/10.1080/13510002.2017.1315513>. Acesso em: 15 set. 2017.1743-2928http://www.repositorio.ufop.br/handle/123456789/9177Oxidative stress, physical inactivity and high-fat (FAT) diets are associated with hepatic disorders such as metabolic syndrome (MS). The therapeutic effects of physical training (PT) were evaluated in rats with MS induced by FAT diet for 13 weeks, on oxidative stress and insulin signaling in the liver, during the last 6 weeks. FAT-sedentary (SED) rats increased body mass, retroperitoneal fat, mean arterial pressure (MAP) and heart rate (HR), and total cholesterol, serum alanine aminotransferase, glucose and insulin. Livers of FAT-SED rats increased superoxide dismutase activity, thiobarbituric acid-reactive substances, protein carbonyl and oxidized glutathione (GSSG); and decreased catalase activity, reduced glutathione/GSSG ratio, and the mRNA expression of insulin receptor substrate 1 (IRS-1) and serine/threonine kinase 2. FAT-PT rats improved in fitness and reduced their body mass, retroperitoneal fat, and glucose, insulin, total cholesterol, MAP and HR; and their livers increased superoxide dismutase and catalase activities, the reduced glutathione/GSSG ratio and the expression of peroxisome proliferator-activated receptor gamma and insulin receptor compared to FAT-SED rats. These findings indicated adaptive responses to PT by restoring the oxidative balance and insulin signaling in the liver and certain biometric and biochemical parameters as well as MAP in MS rats.en-USrestritoPhysical trainingInsulin signaling pathwaySwimming training induces liver adaptations to oxidative stress and insulin sensitivity in rats submitted to high-fat diet.Artigo publicado em periodicohttp://www.tandfonline.com/doi/full/10.1080/13510002.2017.1315513https://doi.org/10.1080/13510002.2017.1315513