Meireles, Augusto Luís Pereira deCosta, Maíra dos SantosRocha, Kelly Alessandra da SilvaGusevskaya, Elena Vitalievna2016-07-292016-07-292015MEIRELES, A. L. P. de et al. Heteropoly acid catalyzed cyclization of nerolidol and farnesol: synthesis of bisabolol. Applied Catalysis. A, General, v. 502, p. 271-275, 2015. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0926860X15300387>. Acesso em: 16 jun. 2016.0926-860Xhttp://www.repositorio.ufop.br/handle/123456789/6684Heteropoly acid H3PW12O40 is an active and environmentally friendly homogeneous catalyst for the synthesis of _-bisabolol, a high-priced and highly demanded ingredient for the fragrance, cosmetic and pharmaceutical industries, starting from more abundant biomass-based sesquiterpenic alcohols. The solvent nature remarkably affects the reaction pathways and product selectivity. In acetone solutions, _-bisabolol can be obtained in 55–60% GC yields from nerolidol and 60–70% GC yields from farnesol at complete substrate conversions, which are probably the best results ever reported for these reactions. _-Bisabolol synthesized by this method contains no farnesol, which is a potentially allergenic compound and should be avoided in the commercially used _-bisabolol. This advantage is especially important because the distillative separation of _-bisabolol and farnesol is a troublesome task. The catalyst shows high turnover numbers and operates under mild nearly ambient conditions.en-USabertoBiomass based feedstockHomogeneous catalysisIsomerizationPolyoxometalatesTerpenesArtigo publicado em periodicoO periódico Applied Catalysis A: General concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3898810874300.https://doi.org/10.1016/j.apcata.2015.06.022