Machado, Vagner de OliveiraAndrade, Ângela LeãoFabris, José DomingosFreitas, Erico Tadeu FragaFerreira, José Maria da FonteSimon, AliceDomingues, Rosana ZacariasFernandez Outon, Luis EugenioCarmo, Flávia Almada doSouza, Antônio Carlos dos SantosCardoso, Hugo Saba Pereira2021-12-092021-12-092021MACHADO, V. de O. et al. Preparation of hybrid nanocomposite particles for medical practices. Colloids and Surfaces A: Physicochemical and Engineering Aspects, v. 624, artigo 126706, 2021. Disponível em: <https://www.sciencedirect.com/science/article/abs/pii/S0927775721005756>. Acesso em: 10 jun. 2021.0927-7757http://www.repositorio.ufop.br/jspui/handle/123456789/14162This study addresses the preparation of hybrid nanoparticles comprised of magnetite (Fe3O4) cores and a surface functionalized with tetramethylammonium hydroxide (TMAOH). The stabilized core nanoparticles were subse quently coated with a polymer matrix consisting of poly(L-co-D,L lactic acid-co-trimethylene carbonate) and poly (ethylene oxide) − poly(propylene oxide) − poly(ethylene oxide) triblock copolymer. The novel core/shell hybrid nanoparticles combine the concepts of electromagnetic heating by the magnetite cores with the drug storage and release ability of the polymeric shell. These multifunctional hybrid nanoparticles are intended for hyperthermia clinical protocols in local drug delivery and medical practices in oncology. The essential physical features of these hybrid composite nanoparticles were assessed using an array of appropriate advanced char acterization techniques. The equivalent average diameters of the composite nanoparticles were relatively uni form and their core/shell mass ratio was estimated through thermogravimetric analysis. The weakening of the intermolecular interactions with decreasing thickness of the coating led to a concomitant decrease in the melting temperature of the shell. The polydispersity index data from dynamic light scattering analysis enabled the conclusion that polymeric species contained in 10 mL of the polymeric matrix solution could effectively coat a maximum of core particles contained in 0.5 mL of ferrofluid.en-USrestritoBiomedical applicationsMagnetic propertiesCoating nanoparticlesCopolymersArtigo publicado em periodicohttps://www.sciencedirect.com/science/article/abs/pii/S0927775721005756https://doi.org/10.1016/j.colsurfa.2021.126706