Vital, Wendel CouraMarques, Marcos JoséGiunchetti, Rodolfo CordeiroCarvalho, Andréa Teixeira deMoreira, Nádia das DoresSouza, Juliana Vitoriano deVieira, Paula Melo de AbreuCarneiro, Cláudia MartinsOliveira, Rodrigo Corrêa deMartins Filho, Olindo AssisCarneiro, MariângelaReis, Alexandre Barbosa2015-03-132015-03-132011VITAL, W. C. et al. Humoral and cellular immune responses in dogs with inapparent natural Leishmania infantum infection. The Veterinary Journal (London, England. 1997), v. 2, p. 23-24, 2011. Disponível em: <http://www.sciencedirect.com/science/article/pii/S1090023311001432>. Acesso em: 08 nov. 2014.1090-0233http://www.repositorio.ufop.br/handle/123456789/4627Molecular analysis, serology and immunophenotyping for T lymphocytes and their subsets, B lymphocytes and monocytes were performed on dogs naturally infected with Leishmania infantum. Animals were categorised as asymptomatic dogs I (AD-I), with negative serology and positive molecular results, and asymptomatic dogs II (AD-II), with positive serology and positive molecular results, and these were compared to symptomatic dogs (SD) and control dogs (CD). AD-I exhibited immunophenotypic features similar to those of CD, including isotype profiles and concentrations of monocytes. Similar biomarkers were found in AD-II and SD, such as, higher levels of immunoglobulins IgG, IgG2, IgM and IgA and higher concentrations of eosinophils. High frequencies of T lymphocytes and CD4+ T cells were observed in both AD-I and AD-II compared to SD, whereas CD8+ T cells were higher only in AD-II compared with SD. Analysis of B lymphocytes revealed an increased frequency of this cell type only in AD-II animals compared with SD. Asymptomatic dogs appear to have a dichotomous infection spectrum that can influence the humoral and cellular immunological status during canine visceral leishmaniasis.en-USCanine visceral leishmaniasisAsymptomatic dogsImmune responseArtigo publicado em periodicoO periódico The Veterinary Journal concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3547120087801.https://doi.org/10.1016/j.tvjl.2011.04.005